Differential Regulation of CYP3A4 and CYP3A5 and its Implication in Drug Discovery

Cancer cells use several mechanisms to resist the cytotoxic effects of drugs, resulting in tumor progression and invasion. One such mechanism capitalizes on the body's natural defense against xenobiotics by increasing the rate of xenobiotic efflux and metabolic inactivation. Xenobiotic metaboli...

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Bibliographic Details

Published in:	Current drug metabolism Vol. 18; no. 12; p. 1095
Main Authors:	Lolodi, Ogheneochukome, Wang, Yue-Ming, Wright, William C, Chen, Taosheng
Format:	Journal Article
Language:	English
Published:	Netherlands 01-01-2017
Subjects:	Antineoplastic Agents - pharmacokinetics Antineoplastic Agents - pharmacology Cytochrome P-450 CYP3A - genetics Cytochrome P-450 CYP3A - metabolism Drug Discovery Gene Expression Regulation, Enzymologic - drug effects Gene Expression Regulation, Neoplastic - drug effects Humans drug-drug interactions drug discovery cytochrome P450 drug resistance CYP3A4 CYP3A5 Cancer
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