Growth factor-like activity of gliadin, an alimentary protein: implications for coeliac disease

Background: Gliadins, a family of wheat proteins, are central to the pathogenesis of celiac disease (CD). In addition to ‘immunogenic’ effects, gliadin directly affects cultured cells and intestine preparations, and produces damage in vivo, via a separate ‘toxic’ peptide, such as A-gliadin p31–43 (P...

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Bibliographic Details
Published in:	Gut Vol. 56; no. 4; pp. 480 - 488
Main Authors:	Barone, Maria V, Gimigliano, Anna, Castoria, Gabriella, Paolella, Giovanni, Maurano, Francesco, Paparo, Franco, Maglio, Maria, Mineo, Alba, Miele, Erasmo, Nanayakkara, Merlin, Troncone, Riccardo, Auricchio, Salvatore
Format:	Journal Article
Language:	English
Published:	London BMJ Publishing Group Ltd and British Society of Gastroenterology 01-04-2007 BMJ BMJ Publishing Group LTD BMJ Group
Subjects:	Actins - metabolism Apoptosis Apoptosis - drug effects Bands Biological and medical sciences Caco-2 Cells Celiac disease Celiac Disease - metabolism Celiac Disease - pathology Cell Cycle - drug effects Cell growth Cell Line Cell Proliferation - drug effects Cloning Coeliac Disease Cytoskeleton - drug effects EGF EGFR Endocytosis - drug effects Epidermal growth factor Epidermal Growth Factor - metabolism epidermal growth factor receptor Gastroenterology. Liver. Pancreas. Abdomen Gliadin - metabolism Gliadin - pharmacology Humans Intestinal Mucosa - drug effects Intestinal Mucosa - metabolism Ligands Medical sciences Organ Culture Techniques Other diseases. Semiology Pathogenesis PDGF peptic-tryptic digest of lactoalbumin peptic-tryptic digests of gliadin Peptides Phosphorylation Platelet derived Growth Factor Polyclonal antibodies PTG PTL Receptor, Epidermal Growth Factor - drug effects Receptor, Epidermal Growth Factor - metabolism Receptor, Epidermal Growth Factor - physiology Signal transduction Small intestine Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Triticum aestivum Immunopathology Pathogenesis Mucosa Coeliac disease Small intestine Protein Epidermal growth factor Intestinal malabsorption Biopsy Gliadin Digestive diseases Intestinal disease Cytoskeleton Growth factor
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