Risk of tuberculosis in patients with HIV-I and HIV-II infections in Abidjan, Ivory Coast

• Published in: BMJ Vol. 302; no. 6775; pp. 496 - 499
• Main Authors: De Cock, K M, Gnaore, E, Adjorlolo, G, Braun, M M, Lafontaine, M F, Yesso, G, Bretton, G, Coulibaly, I M, Gershy-Damet, G M, Bretton, R
• Format: Journal Article
• Language: English
• Published: England British Medical Journal Publishing Group 02-03-1991; British Medical Association; BMJ Publishing Group LTD
• Subjects: Adult; AIDS; AIDS/HIV; Blood donation; Blood Donors; Cote d'Ivoire; Cross-Sectional Studies; Female; HIV; HIV 1; HIV 2; HIV infections; HIV Infections - complications; HIV Infections - epidemiology; human immunodeficiency virus 2; Humans; Infections; Male; Middle Aged; Mycobacterium tuberculosis; Odds Ratio; Prevalence; Pulmonary tuberculosis; Risk Factors; Tuberculosis; Tuberculosis - complications; Tuberculosis, Pulmonary - complications; Cote d'Ivoire
• ISSN: 0959-8138; 1468-5833; 1756-1833
• DOI: 10.1136/bmj.302.6775.496

OBJECTIVE--To examine the association between HIV-II infection and tuberculosis. DESIGN--Cross sectional study comparing the prevalence of HIV-I and HIV-II infections in patients with tuberculosis and in blood donors. SETTING--Abidjan, Ivory Coast, west Africa. PATIENTS--2043 consecutive ambulant patients with tuberculosis (confirmed pulmonary, presumed pulmonary, or extrapulmonary) and 2127 volunteer blood donors. MAIN OUTCOME MEASURE--Prevalence of HIV-I and HIV-II infections as assessed by presence of serum antibodies. RESULTS--Overall rates of HIV infection were 40.2% in patients with tuberculosis (26.4% positive for HIV-I, 4.7% for HIV-II, and 9.0% for both); and 10.4% in blood donors (7.2% positive for HIV-I, 1.9% for HIV-II, and 1.3% for both). HIV-II infection was significantly more common in patients with all types of tuberculosis than in blood donors (97/2043, 4.7% v 40/2127, 1.9%; odds ratio 3.8%, 95% confidence interval 2.6 to 5.6). CONCLUSION--Both HIV-I and HIV-II infections are associated with tuberculosis in Abidjan. 35% of adult tuberculosis in Abidjan is attributable to HIV infection and 4% specifically to HIV-II.