Quantifying clinic transfers among people living with HIV in the Western Cape, South Africa: a retrospective spatial analysis

• Published in: BMJ open Vol. 11; no. 12; p. e055712
• Main Authors: Espinosa Dice, Ana Lucia, Bengtson, Angela M, Mwenda, Kevin M, Colvin, Christopher J, Lurie, Mark N
• Format: Journal Article
• Language: English
• Published: England British Medical Journal Publishing Group 02-12-2021; BMJ Publishing Group LTD; BMJ Publishing Group
• Series: Original research
• Subjects: Ambulatory Care Facilities; Anti-HIV Agents - therapeutic use; Antiretroviral drugs; Clinics; Continuity of care; Datasets; Epidemiology; Female; Health facilities; HIV; HIV Infections - drug therapy; HIV Infections - epidemiology; HIV/AIDS; Human immunodeficiency virus; Humans; Laboratories; Male; Medical records; Mortality; Patients; Pharmacy; Population; Retention; Retrospective Studies; Search engines; South Africa - epidemiology; Spatial Analysis; Trends; South Africa; epidemiology; hiv & aids
• ISSN: 2044-6055; 2044-6055
• DOI: 10.1136/bmjopen-2021-055712

ObjectivesFor persons living with HIV (PLWH) in long-term care, clinic transfers are common and influence sustained engagement in HIV care, as they are associated with significant time out-of-care, low CD4 count, and unsuppressed viral load on re-entry. Despite the geospatial nature of clinic transfers, there exist limited data on the geospatial trends of clinic transfers to guide intervention development. In this study, we investigate the geospatial characteristics and trends of clinic transfers among PLWH on antiretroviral therapy (ART) in the Western Cape Province of South Africa.DesignRetrospective spatial analysis.SettingPLWH who initiated ART treatment between 2012 and 2016 in South Africa’s Western Cape Province were followed from ART initiation to their last visit prior to 2017. Deidentified electronic medical records from all public clinical, pharmacy, and laboratory visits in the Western Cape were linked across space and time using a unique patient identifier number.Participants4176 ART initiators in South Africa (68% women).MethodsWe defined a clinic transfer as any switch between health facilities that occurred on different days and measured the distance between facilities using geodesic distance. We constructed network flow maps to evaluate geospatial trends in clinic transfers over time, both for individuals’ first transfer and overall.ResultsTwo-thirds of ART initiators transferred health facilities at least once during follow-up. Median distance between all clinic transfer origins and destinations among participants was 8.6 km. Participant transfers were heavily clustered around Cape Town. There was a positive association between time on ART and clinic transfer distance, both among participants’ first transfers and overall.ConclusionThis study is among the first to examine geospatial trends in clinic transfers over time among PLWH. Our results make clear that clinic transfers are common and can cluster in urban areas, necessitating better integrated health information systems and HIV care.