Moxifloxacin and bilateral acute iris transillumination

Moxifloxacin and bilateral acute iris transillumination

Recent publications have alerted clinicians to a syndrome of uveitic transilluminating iris depigmentation associated with systemic fluoroquinolones and other antibiotics. Bilateral acute iris transillumination, which is associated with loss of the iris pigment epithelium and results in iris transil...

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Bibliographic Details
Published in:Journal of ophthalmic inflammation and infection Vol. 3; no. 1; p. 10
Main Authors: Knape, Robert M, Sayyad, Fouad E, Davis, Janet L
Format: Journal Article
Language:English
Published: Berlin/Heidelberg Springer Berlin Heidelberg 14-01-2013
Springer Nature B.V
BioMed Central Ltd
Springer
Subjects:
Eye diseases
Eyes & eyesight
Letter to the Editor
Medicine
Medicine & Public Health
Ophthalmology
Pigments
Iris transillumination
Pigment dispersion
Fluoroquinolone
Moxifloxacin
Uveitis
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Summary:Recent publications have alerted clinicians to a syndrome of uveitic transilluminating iris depigmentation associated with systemic fluoroquinolones and other antibiotics. Bilateral acute iris transillumination, which is associated with loss of the iris pigment epithelium and results in iris transillumination, differs from the previously described bilateral acute depigmentation of the iris, which is associated with atrophy of the iris stroma without transillumination. We present a case of fluoroquinolone-associated uveitis with anterior segment optical coherence tomography imaging to highlight some observations about this syndrome. We interpret pharmacokinetic data to help explain why oral, but not topical, moxifloxacin may cause fluoroquinolone-associated uveitis.
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ISSN:1869-5760
1869-5760
DOI:10.1186/1869-5760-3-10