Longevity Pathways (mTOR, SIRT, Insulin/IGF-1) as Key Modulatory Targets on Aging and Neurodegeneration

Recent data from epidemiologic studies have shown that the majority of the public health costs are related to age-related disorders, and most of these diseases can lead to neuronal death. The specific signaling mechanisms underpinning neurodegeneration and aging are incompletely understood. Much wor...

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Bibliographic Details

Published in:	Current topics in medicinal chemistry Vol. 15; no. 21; p. 2116
Main Authors:	Mazucanti, Caio Henrique, Cabral-Costa, João Victor, Vasconcelos, Andrea Rodrigues, Andreotti, Diana Zukas, Scavone, Cristoforo, Kawamoto, Elisa Mitiko
Format:	Journal Article
Language:	English
Published:	United Arab Emirates 07-08-2015
Subjects:	Aging - metabolism Animals Brain - metabolism Humans Insulin - metabolism Insulin-Like Growth Factor I - metabolism Longevity - physiology Molecular Targeted Therapy - methods Neurodegenerative Diseases - drug therapy Neurodegenerative Diseases - metabolism Signal Transduction Sirtuin 1 - genetics Sirtuin 1 - metabolism TOR Serine-Threonine Kinases - metabolism
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