PREP Plus combined postrehabilitation programme to support upper limb recovery in community-dwelling stroke survivors: protocol for a mixed-methods, cluster-assigned feasibility study

• Published in: BMJ open Vol. 13; no. 1; p. e069016
• Main Authors: Pedlow, Katy, McDonough, Suzanne, Klempel, Natalie, Hylands, Jenny, Hughes, Noelene, Campbell, Zoe, Eng, Janice J, Stephenson, Aoife, Kennedy, Niamh
• Format: Journal Article
• Language: English
• Published: England British Medical Journal Publishing Group 20-01-2023; BMJ Publishing Group LTD; BMJ Publishing Group
• Series: Protocol
• Subjects: Caregivers; Feasibility Studies; Fitness training programs; Health care policy; Homework; Humans; Independent Living; Medical personnel; Mixed methods research; Project management; Quality of Life; Randomized Controlled Trials as Topic; Recovery (Medical); Rehabilitation; Rehabilitation Medicine; Stroke; STROKE MEDICINE; Stroke Rehabilitation - methods; Survivors; Therapists; Upper Extremity; United Kingdom > UK; Northern Ireland; STROKE MEDICINE; REHABILITATION MEDICINE; Stroke
• ISSN: 2044-6055; 2044-6055
• DOI: 10.1136/bmjopen-2022-069016

IntroductionPoor recovery of the upper limb following a stroke has been recognised as a significant problem in the UK. Although there is good evidence that early, intense rehabilitation can lead to upper limb recovery, often this is not maintained, with less than 50% of people regaining the ability to use their upper limb for independent function at 6 months. Upper limb recovery potential is reported for many years poststroke, yet current long-term provision is insufficient.Methods and analysis60 participants will be recruited into this feasibility study, with 30 allocated to a Post Rehabilitation Enablement Programme (PREP) alone and 30 allocated to a combined programme, PREP Plus, consisting of PREP and the Graded Repetitive Arm Supplementary Programme (GRASP). We will aim to complete four iterative waves. Within each wave, the intervention design will be refined, based on participant feedback. Within each wave, there will be one cluster unit (one intervention group ;PREP Plus) and one control group ;PREP alone)). A total of five PREP sites within Northern Ireland Health and Social Care Trusts will be used for this study. PREP Plus will have a home exercise component along with exercises logs and a behaviour contract. Qualitative and quantitative measures will evaluate the acceptability and feasibility to determine how feasible it is to embed the intervention into practice, as well as to determine the feasibility of a larger, mixed-methods, randomised controlled trial to assess intervention efficacy. Clinical endpoints will also be explored.Ethics and disseminationThis study has been approved by the Health and Social Care Research Ethics Committee A, IRAS project ID (278620). Participants will provide informed consent prior to participating in the study. Information outlining the purpose of the study, what data will be collected and how the data will be managed will be provided. Results will be published in peer-reviewed journals and any published data will be available on the university data repository. The project management group will advise on different avenues for dissemination to ensure it reaches appropriate audiences.Trial registration numberNCT05090163.