Comparison of accumulation and altered steroid secretion by placental tissue treated with TCDD and natural mixture of PCDDs-PCDFs

Explants of human placental tissue harvested immediately after expulsion were used to determine differences between accumulation of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and polychlorinated dibenzo-p-dioxin (PCDD)-polychlorinated dibenzo-p-furans (PCDF) environmental mixture, and their influenc...

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Bibliographic Details
Published in:	Reproduction (Cambridge, England) Vol. 126; no. 5; pp. 681 - 687
Main Authors:	Augustowska, K, Gregoraszczuk, E EL, Grochowalski, A, Milewicz, T, Mika, M, Krzysiek, J, Chrzaszcz, R
Format:	Journal Article
Language:	English
Published:	Colchester Society for Reproduction and Fertility 01-11-2003 Portland
Subjects:	Analysis of Variance Benzofurans - pharmacology Benzofurans - toxicity Biological and medical sciences Culture Techniques - methods Dehydroepiandrosterone - metabolism Dibenzofurans, Polychlorinated Estradiol - metabolism Estradiol - secretion Female Fundamental and applied biological sciences. Psychology Hormone metabolism and regulation Humans Mammalian female genital system Oxytocin - secretion Placenta - drug effects Placenta - metabolism Placenta - secretion Placental Circulation - drug effects Polychlorinated Dibenzodioxins - analogs & derivatives Polychlorinated Dibenzodioxins - pharmacology Polychlorinated Dibenzodioxins - toxicity Pregnancy Progesterone - metabolism Progesterone - secretion Soil Pollutants - pharmacology Soil Pollutants - toxicity Vertebrates: reproduction Steroid Reproduction Placenta Fetal membrane Endocrine secretion
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