Involvement of Metabolites and Non-coding RNAs in Diseases

• Published in: Current pharmaceutical biotechnology Vol. 24; no. 7; p. 889
• Main Authors: Coskun, Kubra A, Kıyak, Bercem Yeman, Cifci, Kezban Ucar, Kadioglu, Elif, Yurekli, Nazlican, Tutar, Yusuf
• Format: Journal Article
• Language: English
• Published: Netherlands 01-01-2023
• Subjects: Gene Expression Regulation; RNA, Long Noncoding - genetics; RNA, Long Noncoding - metabolism; metabolite analysis; RNAs; disease; Metabolism; non-coding; metabolites
• ISSN: 1873-4316
• DOI: 10.2174/1389201023666220921091240

Non-coding RNAs have a role in gene regulation and cellular metabolism control. Metabolism produces metabolites which are small molecules formed during the metabolic process. So far, a direct relationship between metabolites and genes is not fully established; however, pseudogenes and their progenitor genes regulate health and disease states. Other non-coding RNAs also contribute to this regulation at different cellular processes. Accumulation and depletion of metabolites accompany the dynamic equilibrium of health and disease state. In this study, metabolites, their roles in the cell, and the link between metabolites and non-coding RNAs are discussed.