Interfacing medicinal chemistry with structural bioinformatics: implications for T box riboswitch RNA drug discovery

The T box riboswitch controls bacterial transcription by structurally responding to tRNA aminoacylation charging ratios. Knowledge of the thermodynamic stability difference between two competing structural elements within the riboswitch, the terminator and the antiterminator, is critical for effecti...

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Bibliographic Details
Published in:	BMC bioinformatics Vol. 13 Suppl 2; no. Suppl 2; p. S5
Main Authors:	Jentzsch, Franziska, Hines, Jennifer V
Format:	Journal Article
Language:	English
Published:	England BioMed Central 13-03-2012 BioMed Central Ltd
Subjects:	Amino Acyl-tRNA Synthetases - genetics Aminoacylation Bacteria Binding sites Bioinformatics Competition Computational Biology - methods Conferences Data processing Drug delivery Drug Discovery Drugs Ligands Microbiology Proteins Riboswitch Riboswitches RNA RNA, Bacterial - chemistry Studies Terminator Regions, Genetic Thermodynamics Transcription tRNA
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