Rituximab treatment for peripheral ulcerative keratitis associated with Wegener’s granulomatosis

• Published in: British journal of ophthalmology Vol. 91; no. 10; p. 1414
• Main Authors: Freidlin, Julie, Wong, Ira G, Acharya, Nisha
• Format: Journal Article
• Language: English
• Published: BMA House, Tavistock Square, London, WC1H 9JR BMJ Publishing Group Ltd 01-10-2007; BMJ Publishing Group LTD; BMJ Group
• Subjects: Antibodies, Monoclonal - therapeutic use; Antibodies, Monoclonal, Murine-Derived; Autoimmune diseases; Corneal Ulcer - drug therapy; Granulomatosis with Polyangiitis - complications; Humans; Immunologic Factors - therapeutic use; Letters; Lymphoma; Male; Middle Aged; Rituximab; Treatment Outcome
• ISSN: 0007-1161; 1468-2079
• DOI: 10.1136/bjo.2006.113316

In spite of high dose oral steroids as well as anti-collagenase therapy with vitamin C and doxycycline, a chronic epithelial defect developed and the corneal thinning continued to advance ( fig 1 ). Because of concern over the progression of PUK and the lack of response to standard treatment, the patient received two 1000 mg infusions of rituximab separated by one week.