Macrocyclic lactone anthelmintics: spectrum of activity and mechanism of action

Macrocyclic lactone anthelmintics: spectrum of activity and mechanism of action

Macrocyclic lactones (MLs), exemplified by the prototype of the class, ivermectin (IVM), are mainstays of programs for the control of nematode and arthropod parasites and pests. Since their introduction 30 years ago, research has revealed that they act on a family of ligand-gated chloride channels g...

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Bibliographic Details
Published in:Current pharmaceutical biotechnology Vol. 13; no. 6; p. 866
Main Authors: Geary, Timothy G, Moreno, Yovany
Format: Journal Article
Language:English
Published: Netherlands 01-05-2012
Subjects:
Animals
Anthelmintics - pharmacology
Arthropods - drug effects
Arthropods - metabolism
Chloride Channels - metabolism
Humans
Macrolides - pharmacology
Nematoda - drug effects
Nematoda - metabolism
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Summary:Macrocyclic lactones (MLs), exemplified by the prototype of the class, ivermectin (IVM), are mainstays of programs for the control of nematode and arthropod parasites and pests. Since their introduction 30 years ago, research has revealed that they act on a family of ligand-gated chloride channels gated by glutamate, which is largely restricted to animals in the phyla Nematoda and Arthropoda. Studies on IVM in model organisms have contributed greatly to our understanding of ML pharmacology, but our understanding of the basis for differences among species and among MLs in potency and spectrum remains far from complete.
ISSN:1873-4316
DOI:10.2174/138920112800399077