Targeting the plasmepsin 4 orthologs of Plasmodium sp. with "double drug" inhibitors

Plasmepsin 4 (PM4) is a digestive vacuole enzyme found in all Plasmodium species examined to date. While P. falciparum has three additional aspartic proteinases in its digestive vacuole in addition to plasmepsin 4, other Plasmodium species have only PM4 in their digestive vacuole. Therefore, PM4 may...

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Bibliographic Details
Published in:Protein and peptide letters Vol. 15; no. 9; p. 868
Main Authors: Janka, Linda, Clemente, Jose, Vaiana, N, Sparatore, A, Romeo, Sergio, Dunn, Ben M
Format: Journal Article
Language:English
Published: Netherlands 01-09-2008
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Summary:Plasmepsin 4 (PM4) is a digestive vacuole enzyme found in all Plasmodium species examined to date. While P. falciparum has three additional aspartic proteinases in its digestive vacuole in addition to plasmepsin 4, other Plasmodium species have only PM4 in their digestive vacuole. Therefore, PM4 may be a good target for the development of an antimalarial drug. This study presents data obtained with PM4s from several Plasmodium species. Low nanomolar K(i) values have been observed for all PM4s studied.
ISSN:0929-8665
DOI:10.2174/092986608785849218