GATA4 and GATA5 are essential for heart and liver development in Xenopus embryos

GATA factors 4/5/6 have been implicated in the development of the heart and endodermal derivatives in vertebrates. Work in zebrafish has indicated that GATA5 is required for normal development earlier than GATA4/6. However, the GATA5 knockout mouse has no apparent embryonic phenotype, thereby questi...

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Bibliographic Details
Published in:	BMC developmental biology Vol. 8; no. 1; p. 74
Main Authors:	Haworth, Kim E, Kotecha, Surendra, Mohun, Timothy J, Latinkic, Branko V
Format:	Journal Article
Language:	English
Published:	England BioMed Central Ltd 28-07-2008 BioMed Central
Subjects:	Animals Danio rerio DNA binding proteins Freshwater GATA4 Transcription Factor - physiology GATA5 Transcription Factor - physiology Genetic aspects Genetic regulation Health aspects Heart - embryology Liver - embryology Physiological aspects Xenopus Xenopus - embryology Xenopus Proteins - physiology Zinc Fingers United Kingdom
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