Medicinal Chemistry Perspective of Fused Isoxazole Derivatives

Nitrogen containing heterocyclic rings with an oxygen atom is considered as one of the best combination in medicinal chemistry due to their diversified biological activities. Isoxazole, a five membered heterocyclic azole ring is found in naturally occuring ibetonic acid along with some of the market...

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Bibliographic Details
Published in:	Current topics in medicinal chemistry Vol. 16; no. 26; p. 2863
Main Authors:	Barmade, Mahesh A, Murumkar, Prashant R, Sharma, Mayank Kumar, Yadav, Mange Ram
Format:	Journal Article
Language:	English
Published:	United Arab Emirates 01-10-2016
Subjects:	Antineoplastic Agents - chemistry Antineoplastic Agents - therapeutic use Cardiovascular Diseases - drug therapy Central Nervous System Diseases - drug therapy Chemistry, Pharmaceutical Humans Hypoglycemic Agents - chemistry Hypoglycemic Agents - therapeutic use Isoxazoles - chemistry Isoxazoles - pharmacology Isoxazoles - therapeutic use Structure-Activity Relationship
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Summary:	Nitrogen containing heterocyclic rings with an oxygen atom is considered as one of the best combination in medicinal chemistry due to their diversified biological activities. Isoxazole, a five membered heterocyclic azole ring is found in naturally occuring ibetonic acid along with some of the marketed drugs such as valdecoxib, flucloxacillin, cloxacillin, dicloxacillin, and danazol. It is also significant for showing antipsychotic activity in risperidone and anticonvulsant activity in zonisamide, the marketed drugs. This review article covers research articles reported till date covering biological activity along with SAR of fused isoxazole derivatives.
ISSN:	1873-4294
DOI:	10.2174/1568026616666160506145700