Development of Thiazole-5-carboxylate Derivatives as Selective Inhibitors of Monoacylglycerol Lipase as Target in Cancer

The signalling function of 2-arachidonoylglycerol (2-AG) in endocannabinoid system is delineated by Monoacylglycerol lipase (MAGL). MAGL readdresses the lipid stores in the direction of pro-tumorigenic signalling lipids in cancer cells. Selective as well as potent MAGL inhibitors are limited in numb...

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Bibliographic Details
Published in:	Mini reviews in medicinal chemistry Vol. 19; no. 5; p. 410
Main Authors:	Ali, Md Rahmat, Kumar, Suresh, Shalmali, Nishtha, Afzal, Obaid, Azim, Sabir, Chanana, Damini, Alam, Ozair, Paudel, Yam Nath, Sharma, Manju, Bawa, Sandhya
Format:	Journal Article
Language:	English
Published:	Netherlands 01-01-2019
Subjects:	Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Arachidonic Acids - metabolism Breast Neoplasms - drug therapy Breast Neoplasms - enzymology Breast Neoplasms - metabolism Carcinoma, Non-Small-Cell Lung - drug therapy Carcinoma, Non-Small-Cell Lung - enzymology Carcinoma, Non-Small-Cell Lung - metabolism Cell Line, Tumor Endocannabinoids - metabolism Enzyme Inhibitors - chemistry Enzyme Inhibitors - pharmacology Female Glycerides - metabolism Humans Lung Neoplasms - drug therapy Lung Neoplasms - enzymology Lung Neoplasms - metabolism Molecular Docking Simulation Monoacylglycerol Lipases - antagonists & inhibitors Monoacylglycerol Lipases - chemistry Monoacylglycerol Lipases - metabolism Neoplasms - drug therapy Neoplasms - enzymology Neoplasms - metabolism Structure-Activity Relationship Thiazoles - chemistry Thiazoles - pharmacology endocannabinoid system (ECS) Monoacylglycerol lipase Endocannabinoid Breast Cancer NCI 60 cell line Thiazole 2-arachidonoylglycerol
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