Identification of BACE2 as an avid ß-amyloid-degrading protease

Proteases that degrade the amyloid ß-protein (Aß) have emerged as key players in the etiology and potential treatment of Alzheimer's disease (AD), but it is unlikely that all such proteases have been identified. To discover new Aß-degrading proteases (AßDPs), we conducted an unbiased, genome-sc...

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Bibliographic Details
Published in:	Molecular neurodegeneration Vol. 7; no. 1; p. 46
Main Authors:	Abdul-Hay, Samer O, Sahara, Tomoko, McBride, Melinda, Kang, Dongcheul, Leissring, Malcolm A
Format:	Journal Article
Language:	English
Published:	England BioMed Central Ltd 17-09-2012 BioMed Central BMC
Subjects:	Advertising executives Alzheimer disease Alzheimer Disease - enzymology Alzheimer Disease - genetics Alzheimer's disease Amyloid - metabolism Amyloid beta-protein Amyloid Precursor Protein Secretases - genetics Amyloid Precursor Protein Secretases - metabolism Amyloid-ß-protein Aspartic Acid Endopeptidases - genetics Aspartic Acid Endopeptidases - metabolism Care and treatment Cells, Cultured Development and progression Endothelin Endothelin-Converting Enzymes Functional screen Gene therapy Genomics Humans Insulysin - metabolism Metalloendopeptidases - metabolism Neprilysin - metabolism Protease Proteases Proteolysis Proteolytic degradation ß-site APP-cleaving enzyme-1 ß-site APP-cleaving enzyme-2
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