The spectrum of histopathological changes encountered in pancreatectomy specimens after neoadjuvant chemoradiation, including subtle and less-well-recognised changes

Preoperative (neoadjuvant) chemoradiation therapy/treatment (NCRT) is emerging as an important treatment modality in borderline resectable pancreatic ductal adenocarcinoma (PDAC). The constellation of histopathological changes secondary to chemoradiation is diverse and has been well documented, part...

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Bibliographic Details
Published in:	Journal of clinical pathology Vol. 69; no. 6; p. 463
Main Authors:	Kalimuthu, Sangeetha N, Serra, Stefano, Dhani, Neesha, Chetty, Runjan
Format:	Journal Article
Language:	English
Published:	England 01-06-2016
Subjects:	Biopsy Carcinoma, Pancreatic Ductal - pathology Carcinoma, Pancreatic Ductal - surgery Carcinoma, Pancreatic Ductal - therapy Chemoradiotherapy, Adjuvant Humans Neoadjuvant Therapy Pancreas - pathology Pancreas - surgery Pancreatectomy Pancreatic Neoplasms Pancreatic Neoplasms - pathology Pancreatic Neoplasms - surgery Pancreatic Neoplasms - therapy PANCREAS CARCINOMA CHEMOTHERAPY
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Summary:	Preoperative (neoadjuvant) chemoradiation therapy/treatment (NCRT) is emerging as an important treatment modality in borderline resectable pancreatic ductal adenocarcinoma (PDAC). The constellation of histopathological changes secondary to chemoradiation is diverse and has been well documented, particularly in other gastrointestinal organs such as the oesophagus and colorectum. However, the histological changes specific to the pancreas have not been fully characterised and described. This review aims to provide a detailed catalogue of histological features associated with NCRT-treated PDAC and highlight any subtle, less-recognised changes.
ISSN:	1472-4146
DOI:	10.1136/jclinpath-2016-203604