The vasculature as a target in the treatment of pulmonary emphysema

Pulmonary emphysema, a major component of chronic obstructive pulmonary diseases, is a highly prevalent progressive tissue-destructive disease, with no effective treatments. The interplay between inflammation, matrix proteolysis, oxidative stress and apoptosis might account for the irreversible prog...

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Bibliographic Details
Published in:	Current drug targets Vol. 7; no. 6; p. 737
Main Authors:	Golpon, H A, Voelkel, N F
Format:	Journal Article
Language:	English
Published:	United Arab Emirates 01-06-2006
Subjects:	Animals Apoptosis - drug effects Capillaries - drug effects Capillaries - immunology Capillaries - pathology Humans Lung - blood supply Lung - immunology Lung - pathology Oxidative Stress - drug effects Pulmonary Emphysema - immunology Pulmonary Emphysema - pathology Pulmonary Emphysema - therapy Respiratory System Agents - therapeutic use
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Summary:	Pulmonary emphysema, a major component of chronic obstructive pulmonary diseases, is a highly prevalent progressive tissue-destructive disease, with no effective treatments. The interplay between inflammation, matrix proteolysis, oxidative stress and apoptosis might account for the irreversible progression of the disease. Recent investigations have underlined the importance of the lung vasculature in the pathobiology of chronic obstructive pulmonary diseases offering new therapeutic strategies. This review will focus on the pulmonary microvessels as a target in the treatment of pulmonary emphysema.
ISSN:	1389-4501
DOI:	10.2174/138945006777435335