Folate supplementation reduces serum Hsp70 levels in patients with type 2 diabetes

Type 2 diabetes patients are subject to oxidative stress as a result of hyperglycemia. The aim of this study was to determine whether administration of the antioxidant folic acid, previously shown to reduce homocysteine levels, would reduce circulating levels of Hsp70 while improving the condition o...

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Published in:	Cell stress & chaperones Vol. 9; no. 4; pp. 344 - 349
Main Authors:	Hunter-Lavin, Claire, Hudson, Peter R., Mukherjee, Sagarika, Davies, Gareth K., Williams, Clive P., Harvey, John N., Child, David F., Williams, John H. H.
Format:	Journal Article
Language:	English
Published:	Netherlands Cell Stress Society International 01-12-2004
Subjects:	Acid treatment Blood plasma Chaperonin 60 - immunology Diabetes Mellitus, Type 2 - metabolism Dietary Supplements Erythrocytes - metabolism Folic Acid - metabolism Heat shock proteins HSP70 Heat-Shock Proteins - immunology HSP70 Heat-Shock Proteins - metabolism Humans Insulin Original Original s Oxidative stress P values Type 1 diabetes mellitus Type 2 diabetes mellitus Urine Vascular diseases
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Abstract	Type 2 diabetes patients are subject to oxidative stress as a result of hyperglycemia. The aim of this study was to determine whether administration of the antioxidant folic acid, previously shown to reduce homocysteine levels, would reduce circulating levels of Hsp70 while improving the condition of type 2 diabetes patients with microalbuminuria. Plasma homocysteine fell from pretreatment values of 12.9 to 10.3 μM (P < 0.0001). The urine albumin-creatinine ratio fell from 12.4 to 10.4 mg/mM (P = 0.38). Pretreatment Hsp70 levels were higher in patients not taking insulin (5.32 ng/mL) compared with those on insulin (2.44 ng/mL) (P = 0.012). Folic acid supplementation resulted in a significant fall in Hsp70 (5.32 to 2.05 ng/mL) (P = 0.004). There was no change in Hsp70 in those receiving insulin. Folic acid supplementation in non–insulin-treated type 2 diabetes patients, therefore, resulted in a fall in Hsp70, reflecting an improvement in oxidative stress. The data shows that improvement in homocysteine status can lead to a reduction in Hsp70, indicating the possibility of its use as a marker for severity of disease.
AbstractList	Type 2 diabetes patients are subject to oxidative stress as a result of hyperglycemia. The aim of this study was to determine whether administration of the antioxidant folic acid, previously shown to reduce homocysteine levels, would reduce circulating levels of Hsp70 while improving the condition of type 2 diabetes patients with microalbuminuria. Plasma homocysteine fell from pretreatment values of 12.9 to 10.3 μM (P < 0.0001). The urine albumin-creatinine ratio fell from 12.4 to 10.4 mg/mM (P = 0.38). Pretreatment Hsp70 levels were higher in patients not taking insulin (5.32 ng/mL) compared with those on insulin (2.44 ng/mL) (P = 0.012). Folic acid supplementation resulted in a significant fall in Hsp70 (5.32 to 2.05 ng/mL) (P = 0.004). There was no change in Hsp70 in those receiving insulin. Folic acid supplementation in non-insulin-treated type 2 diabetes patients, therefore, resulted in a fall in Hsp70, reflecting an improvement in oxidative stress. The data shows that improvement in homocysteine status can lead to a reduction in Hsp70, indicating the possibility of its use as a marker for severity of disease. Type 2 diabetes patients are subject to oxidative stress as a result of hyperglycemia. The aim of this study was to determine whether administration of the antioxidant folic acid, previously shown to reduce homocysteine levels, would reduce circulating levels of Hsp70 while improving the condition of type 2 diabetes patients with microalbuminuria. Plasma homocysteine fell from pretreatment values of 12.9 to 10.3 microM (P < 0.0001). The urine albumin-creatinine ratio fell from 12.4 to 10.4 mg/mM (P = 0.38). Pretreatment Hsp70 levels were higher in patients not taking insulin (5.32 ng/mL) compared with those on insulin (2.44 ng/mL) (P = 0.012). Folic acid supplementation resulted in a significant fall in Hsp70 (5.32 to 2.05 ng/mL) (P = 0.004). There was no change in Hsp70 in those receiving insulin. Folic acid supplementation in non-insulin-treated type 2 diabetes patients, therefore, resulted in a fall in Hsp70, reflecting an improvement in oxidative stress. The data shows that improvement in homocysteine status can lead to a reduction in Hsp70, indicating the possibility of its use as a marker for severity of disease. Type 2 diabetes patients are subject to oxidative stress as a result of hyperglycemia. The aim of this study was to determine whether administration of the antioxidant folic acid, previously shown to reduce homocysteine levels, would reduce circulating levels of Hsp70 while improving the condition of type 2 diabetes patients with microalbuminuria. Plasma homocysteine fell from pretreatment values of 12.9 to 10.3 μM ( P < 0.0001). The urine albumin-creatinine ratio fell from 12.4 to 10.4 mg/mM ( P = 0.38). Pretreatment Hsp70 levels were higher in patients not taking insulin (5.32 ng/mL) compared with those on insulin (2.44 ng/mL) ( P = 0.012). Folic acid supplementation resulted in a significant fall in Hsp70 (5.32 to 2.05 ng/mL) ( P = 0.004). There was no change in Hsp70 in those receiving insulin. Folic acid supplementation in non–insulin-treated type 2 diabetes patients, therefore, resulted in a fall in Hsp70, reflecting an improvement in oxidative stress. The data shows that improvement in homocysteine status can lead to a reduction in Hsp70, indicating the possibility of its use as a marker for severity of disease. Type 2 diabetes patients are subject to oxidative stress as a result of hyperglycemia. The aim of this study was to determine whether administration of the antioxidant folic acid, previously shown to reduce homocysteine levels, would reduce circulating levels of Hsp70 while improving the condition of type 2 diabetes patients with microalbuminuria. Plasma homocysteine fell from pretreatment values of 12.9 to 10.3 microM (P < 0.0001). The urine albumin-creatinine ratio fell from 12.4 to 10.4 mg/mM (P = 0.38). Pretreatment Hsp70 levels were higher in patients not taking insulin (5.32 ng/mL) compared with those on insulin (2.44 ng/mL) (P = 0.012). Folic acid supplementation resulted in a significant fall in Hsp70 (5.32 to 2.05 ng/mL) (P = 0.004). There was no change in Hsp70 in those receiving insulin. Folic acid supplementation in non-insulin-treated type 2 diabetes patients, therefore, resulted in a fall in Hsp70, reflecting an improvement in oxidative stress. The data shows that improvement in homocysteine status can lead to a reduction in Hsp70, indicating the possibility of its use as a marker for severity of disease.
Author	Hudson, Peter R. Williams, John H. H. Child, David F. Harvey, John N. Davies, Gareth K. Williams, Clive P. Hunter-Lavin, Claire Mukherjee, Sagarika
AuthorAffiliation	2 Departments of Medical Biochemistry and Diabetes Medicine, Wrexham Maelor Hospital, North East Wales NHS Trust, Wrexham, LL13 7TD, UK 1 Chester Centre for Stress Research, Department of Biological Sciences, University College Chester, Parkgate Road, Chester, CH1 4BJ, UK
AuthorAffiliation_xml	– name: 1 Chester Centre for Stress Research, Department of Biological Sciences, University College Chester, Parkgate Road, Chester, CH1 4BJ, UK – name: 2 Departments of Medical Biochemistry and Diabetes Medicine, Wrexham Maelor Hospital, North East Wales NHS Trust, Wrexham, LL13 7TD, UK
Author_xml	– sequence: 1 givenname: Claire surname: Hunter-Lavin fullname: Hunter-Lavin, Claire organization: Chester Centre for Stress Research, Department of Biological Sciences, University College Chester, Parkgate Road, Chester, CH1 4BJ, UK – sequence: 2 givenname: Peter R. surname: Hudson fullname: Hudson, Peter R. organization: Departments of Medical Biochemistry and Diabetes Medicine, Wrexham Maelor Hospital, North East Wales NHS Trust, Wrexham, LL13 7TD, UK – sequence: 3 givenname: Sagarika surname: Mukherjee fullname: Mukherjee, Sagarika organization: Departments of Medical Biochemistry and Diabetes Medicine, Wrexham Maelor Hospital, North East Wales NHS Trust, Wrexham, LL13 7TD, UK – sequence: 4 givenname: Gareth K. surname: Davies fullname: Davies, Gareth K. organization: Departments of Medical Biochemistry and Diabetes Medicine, Wrexham Maelor Hospital, North East Wales NHS Trust, Wrexham, LL13 7TD, UK – sequence: 5 givenname: Clive P. surname: Williams fullname: Williams, Clive P. organization: Departments of Medical Biochemistry and Diabetes Medicine, Wrexham Maelor Hospital, North East Wales NHS Trust, Wrexham, LL13 7TD, UK – sequence: 6 givenname: John N. surname: Harvey fullname: Harvey, John N. organization: Departments of Medical Biochemistry and Diabetes Medicine, Wrexham Maelor Hospital, North East Wales NHS Trust, Wrexham, LL13 7TD, UK – sequence: 7 givenname: David F. surname: Child fullname: Child, David F. organization: Departments of Medical Biochemistry and Diabetes Medicine, Wrexham Maelor Hospital, North East Wales NHS Trust, Wrexham, LL13 7TD, UK – sequence: 8 givenname: John H. H. surname: Williams fullname: Williams, John H. H. organization: Chester Centre for Stress Research, Department of Biological Sciences, University College Chester, Parkgate Road, Chester, CH1 4BJ, UK
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Cites_doi	10.2337/diabetes.52.9.2338 10.1002/jcp.1041380206 10.1016/S0021-9150(02)00191-0 10.1136/bmj.325.7374.1202 10.1016/S0140-6736(03)14075-5 10.2337/diacare.25.3.537 10.1146/annurev.ge.22.120188.003215 10.1093/ndt/15.4.524 10.1093/jn/126.suppl_4.1276S 10.3109/02656739409009359 10.1172/JCI10588 10.1016/S0002-9343(02)01075-6 10.1007/s001090050298 10.1046/j.1523-1755.1999.00256.x 10.2337/diab.46.2.232 10.1038/sj.ejcn.1601554 10.3109/08820139809022710 10.1016/S1262-3636(03)72787-6 10.1016/0168-8227(95)01151-X 10.1001/jama.1995.03530130055028 10.1042/cs1000111 10.1016/S0735-1097(99)00469-6 10.1016/S0026-0495(98)90344-4 10.2337/diacare.22.9.1597 10.1074/jbc.M002265200 10.1042/bj3320213 10.1136/bmj.316.7135.894 10.1007/s003800070043 10.1016/S0169-328X(00)00208-4 10.2337/diacare.21.5.841 10.1080/095530096145076 10.1074/jbc.275.1.189
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Notes	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Correspondence to: John Williams, Tel: 01244 392704; Fax: 01244 392781; john.williams@chester.ac.uk
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Snippet	Type 2 diabetes patients are subject to oxidative stress as a result of hyperglycemia. The aim of this study was to determine whether administration of the...
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SubjectTerms	Acid treatment Blood plasma Chaperonin 60 - immunology Diabetes Mellitus, Type 2 - metabolism Dietary Supplements Erythrocytes - metabolism Folic Acid - metabolism Heat shock proteins HSP70 Heat-Shock Proteins - immunology HSP70 Heat-Shock Proteins - metabolism Humans Insulin Original Original s Oxidative stress P values Type 1 diabetes mellitus Type 2 diabetes mellitus Urine Vascular diseases
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Title	Folate supplementation reduces serum Hsp70 levels in patients with type 2 diabetes
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