Huntington's disease

• Published in: Molecular pathology Vol. 54; no. 6; pp. 409 - 413
• Main Authors: Davies, S, Ramsden, D B
• Format: Journal Article
• Language: English
• Published: England BMJ Publishing Group Ltd and Association of Clinical Pathologists 01-12-2001; BMJ Publishing Group Ltd; British Medical Journal Publishing Group
• Subjects: Apoptosis; Brain-Derived Neurotrophic Factor - metabolism; Carrier Proteins - metabolism; Cell Death; Cell Nucleus - metabolism; Cytoplasm - metabolism; Degeneration; Development and progression; DNA-Binding Proteins; Humans; Huntingtin; Huntingtin Protein; Huntington Disease - genetics; Huntington Disease - metabolism; Huntington Disease - pathology; Huntington's chorea; Huntington's disease; kainate receptors; Models, Neurological; Nerve Tissue Proteins - genetics; Nerve Tissue Proteins - metabolism; Nervous system; neurodegenerative disorder; Neurons - metabolism; Neurons - pathology; Neurotoxins - metabolism; NMDA receptors; Nuclear Proteins - genetics; Nuclear Proteins - metabolism; Oxidative Stress; Receptors, N-Methyl-D-Aspartate - metabolism; Review; Trinucleotide Repeat Expansion; United Kingdom
• ISSN: 1366-8714; 1472-4154
• DOI: 10.1136/mp.54.6.409

The most recent findings in the elucidation of the molecular pathology of Huntington's disease are reviewed. Particular interest has been paid to the role of huntingtin and its associated proteins in excitotoxicity mediated via NMDA and kainate receptors.