Progressive supranuclear palsy

• Published in: Molecular pathology Vol. 54; no. 6; pp. 427 - 434
• Main Authors: Tawana, K, Ramsden, D B
• Format: Journal Article
• Language: English
• Published: England BMJ Publishing Group Ltd and Association of Clinical Pathologists 01-12-2001; BMJ Publishing Group Ltd; British Medical Journal Publishing Group
• Subjects: Brain - metabolism; Brain - pathology; Cell Death; Degeneration; Development and progression; Humans; Microtubules - metabolism; Nervous system; neurodegenerative disease; Neurofibrillary Tangles - metabolism; Neurofibrillary Tangles - pathology; Neurons - metabolism; Neurons - pathology; Oxidative Stress; Polymorphism, Genetic; Progressive supranuclear palsy; Protein Isoforms - genetics; Protein Isoforms - metabolism; Review; Supranuclear Palsy, Progressive - genetics; Supranuclear Palsy, Progressive - metabolism; Supranuclear Palsy, Progressive - pathology; tau Proteins - genetics; tau Proteins - metabolism; τ protein filaments; United Kingdom
• ISSN: 1366-8714; 1472-4154
• DOI: 10.1136/mp.54.6.427

This review concentrates on the molecular pathology of the protein τ, including its expression in various regions of the brain. The role of post-translational modifications in fibrillogenesis is also discussed, particularly hyperphosphorylation and glycation. However, the initiating event that causes aberrant τ processing remains unclear.