The aetiology of idiopathic Parkinson's disease

• Published in: Molecular pathology Vol. 54; no. 6; pp. 369 - 380
• Main Authors: Ramsden, D B, Parsons, R B, Ho, S L, Waring, R H
• Format: Journal Article
• Language: English
• Published: England BMJ Publishing Group Ltd and Association of Clinical Pathologists 01-12-2001; BMJ Publishing Group Ltd; British Medical Journal Publishing Group
• Subjects: Animals; Brain - metabolism; C-Reactive Protein - genetics; C-Reactive Protein - metabolism; Causes of; Cysteine Dioxygenase; Dioxygenases; Dopamine - metabolism; environmental agents; Homeodomain Proteins - genetics; Homeodomain Proteins - metabolism; Humans; LIM-Homeodomain Proteins; Models, Animal; Mutation; Neurons - physiology; Neurotoxins - metabolism; Oxygenases - metabolism; parkin; Parkinson Disease - etiology; Parkinson Disease - genetics; Parkinson Disease - metabolism; Parkinson's disease; Review; Serum Amyloid P-Component - genetics; Serum Amyloid P-Component - metabolism; Transcription Factors; ubiquitin carboxy terminal hydroxylase L1; Zinc Fingers - physiology; α synuclein; United Kingdom
• ISSN: 1366-8714; 1472-4154
• DOI: 10.1136/mp.54.6.369

Agents potentially involved in the aetiology of idiopathic Parkinson's disease are discussed. These include factors regulating dopaminergic neurogenesis (Nurr 1, Ptx-3, and Lmx1b) and related proteins, together with genes involved in familial Parkinson's disease (α synuclein, parkin, and ubiquitin carboxy terminal hydroxylase L1), and endogenous and environmental agents.