Ester Prodrugs of Ketoprofen: Synthesis, In Vitro Stability, In Vivo Biological Evaluation and In Silico Comparative Docking Studies Against COX-1 and COX-2

Prompted by the ineptness of the currently used non-steroidal antiinflammatory drugs (NSAIDs) to control gastric mucosal and renal adverse reactions, several ester prodrugs of ketoprofen were synthesized and characterized by IR, 1H NMR and mass spectral data. Physicochemical properties such as aqueo...

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Bibliographic Details
Published in:	Current drug discovery technologies Vol. 13; no. 1; p. 41
Main Authors:	Ahmed, Musa, Azam, Faizul, Gbaj, Abdul, Zetrini, Abdulmottaleb E, Abodlal, Amna Salem, Rghigh, Abir, Elmahdi, Eman, Hamza, Amel, Salama, Mabruk, Bensaber, Salah M
Format:	Journal Article
Language:	English
Published:	United Arab Emirates 01-03-2016
Subjects:	Animals Anti-Inflammatory Agents, Non-Steroidal - chemical synthesis Anti-Inflammatory Agents, Non-Steroidal - chemistry Crystallography, X-Ray Cyclooxygenase 1 - chemistry Cyclooxygenase 2 - chemistry Drug Stability Esters - chemistry Ketoprofen - chemical synthesis Ketoprofen - chemistry Male Molecular Docking Simulation Prodrugs - chemical synthesis Prodrugs - chemistry Rats Rats, Wistar Spectrum Analysis - methods
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