Systemic Lupus Erythematosus: Correlation Between Immunodysregulation and Clinical Manifestations

Systemic Lupus Erythematosus is considered a prototype of an autoimmune disorder. The greatly compromise immune system reflects in a global loss of self-tolerance and an array of autoantibodies which are the hallmark of the disease. Diagnosis and clinical management are a challenge to physicians owi...

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Bibliographic Details
Published in:	Current rheumatology reviews Vol. 12; no. 2; p. 154
Main Authors:	Carneiro, O Ismael P, Brito, Iva H O
Format:	Journal Article
Language:	English
Published:	United Arab Emirates 01-08-2016
Subjects:	Autoantibodies - immunology Autoantigens - immunology Humans Lupus Erythematosus, Systemic - immunology Lupus Erythematosus, Systemic - pathology
Online Access:	Get more information
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Summary:	Systemic Lupus Erythematosus is considered a prototype of an autoimmune disorder. The greatly compromise immune system reflects in a global loss of self-tolerance and an array of autoantibodies which are the hallmark of the disease. Diagnosis and clinical management are a challenge to physicians owing its complex clinical course. Specific correlation between immunodysregulation and the clinical manifestations have been studied and we intended in this paper to review recent studies, highlighting new discoveries in this matter.
ISSN:	1875-6360
DOI:	10.2174/1573397111666151026223228