Onset and duration of cycloplegic action of 1% cyclopentolate - 1% tropicamide combination

• Published in: African health sciences Vol. 17; no. 3; pp. 923 - 932
• Main Authors: Kyei, Samuel, Nketsiah, Alfred Asiem, Asiedu, Kofi, Awuah, Agnes, Owusu-Ansah, Andrew
• Format: Journal Article
• Language: English
• Published: Uganda Makerere University Medical School 01-09-2017; Makerere Medical School
• Subjects: accommodation; Accommodation, Ocular - drug effects; Cyclopentolate - administration & dosage; Cycloplegia; Dose-Response Relationship, Drug; Female; Humans; Male; Mydriatics - administration & dosage; Ophthalmic Solutions - administration & dosage; Pupil - drug effects; recovery time; time course; Time Factors; Tropicamide - administration & dosage; accommodation; time course; Cycloplegia; recovery time
• ISSN: 1680-6905; 1729-0503; 1680-6905
• DOI: 10.4314/ahs.v17i3.36

Purpose: To study the time course (onset, time and duration of maximal
cycloplegia, and the full duration) of cycloplegic action of 1%
Cyclopentolate - 1% Tropicamide. Methods: Seventy-seven students,
aged 15-24 years were purposively sampled from the University of Cape
Coast and Cape Coast Technical Institute. Subjective near addition
(ADD) determination and pupil diameter measurement before and after a
drop of the test agent (1% Cyclopentolate - 1% Tropicamide
combination in the right eye) and the control (1% Cyclopentolate in the
left eye) were performed. Measurements of subjective near ADD and pupil
diameter were made after the initial reading at 5 minutes interval for
the first hour and every 30 minutes for the next 7 hours for each
participant. Time of onset, time of peak cycloplegia, duration of peak
cycloplegia and duration of total cycloplegic effect was indirectly
determined. Results: 1% Cyclopentolate - 1% Tropicamide
combination had rapid onset of cycloplegia (5-10 minutes), shorter time
of maximal cycloplegia (55 versus 90 minutes), and recovery (7 versus
≥ 8hours) in the majority (79.2%) of subjects. Conclusion:
Cyclopentolate -Tropicamide combination was comparable to
Cyclopentolate in depth of cycloplegia produced, and clinically
superior to 1% Cyclopentolate in rapidity of cycloplegic onset, time of
maximal cycloplegia and recovery from cycloplegia.