Primary epithelial amyloid keratopathy with multiple recurrences in grafts

• Published in: British journal of ophthalmology Vol. 82; no. 3; pp. 326 - e331
• Main Authors: WYGNANSKI-JAFFE, TAMARA, AVNI, ISAAC, BRIKMAN, IGOR, ROSNER, MORDECHAI
• Format: Journal Article
• Language: English
• Published: England BMJ Publishing Group LTD 01-03-1998
• Subjects: Age; Amyloidosis - complications; Amyloidosis - pathology; Cornea; Corneal Diseases - complications; Corneal Diseases - pathology; Corneal Dystrophies, Hereditary - diagnosis; Humans; Keratoplasty, Penetrating; Letters to the Editor; Male; Microscopy; Middle Aged; Recurrence; Reoperation; Stromal Cells; Vision Disorders - etiology
• ISSN: 0007-1161; 1468-2079
• DOI: 10.1136/bjo.82.3.e326

COMMENT Primary epithelial amyloid keratopathy (PEAK) is a variant of primary gelatinous corneal dystrophy, first described in 1994 by Edward and co-workers in patients who were of Asian-Indian or Iraqi origin 1 ; another variant is primary drop-like corneal dystrophy which has been mainly described in Japan. 2 3 Patients with PEAK suffer from deterioration of vision, redness, and photophobia from childhood or adolescence whereas in primary gelatinous corneal dystrophy symptoms usually start at adulthood. [...]PEAK is an aggressive variant of primary gelatinous corneal dystrophy, demonstrating a devastating corneal disease starting at young age and no remedy even after corneal scraping or repeated penetrating keratoplasty.