Extrahepatic biliary atresia with cartilaginous metaplasia in the gallbladder remnants

Extrahepatic biliary atresia with cartilaginous metaplasia in the gallbladder remnants

Extrahepatic biliary atresia (EBA) is a chronic inflammatory process leading to fibrous obliteration of the biliary tree. Cartilaginous metaplasia within the remaining walls of the biliary main ducts in EBA has been reported once, although as cartilage heterotopia. A similar finding is presented her...

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Bibliographic Details
Published in:Journal of clinical pathology Vol. 61; no. 8; p. 965
Main Authors: Altamirano, E, Drut, R
Format: Journal Article
Language:English
Published: England 01-08-2008
Subjects:
Bile Ducts, Extrahepatic - pathology
Biliary Atresia - pathology
Cartilage - pathology
Gallbladder - abnormalities
Gallbladder - pathology
Humans
Infant
Metaplasia - pathology
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Description
Summary:Extrahepatic biliary atresia (EBA) is a chronic inflammatory process leading to fibrous obliteration of the biliary tree. Cartilaginous metaplasia within the remaining walls of the biliary main ducts in EBA has been reported once, although as cartilage heterotopia. A similar finding is presented here, but in the gallbladder of an infant with the full-blown manifestations of EBA; it is proposed that the alteration results from metaplasia of local connective tissue. Also of note is the complete disappearance of smooth muscle cells in the walls of the biliary tree in EBA, a fact which seems to be missing in the description of the pathology in these cases.
ISSN:1472-4146
DOI:10.1136/jcp.2006.045831