A Biotechnological Review on Patents Applied to Rubella Diagnosis

• Published in: Recent patents on biotechnology Vol. 17; no. 4; p. 332
• Main Authors: da Silva, Jonatas Oliveira, Dos Santos, Michelli, Silva, Ana Amélia Maia, Ferreira, André Vinícius Fernandes, Nogueira, Laís Moreira, Gandra, Isadora Braga, Junior, Silvio José Elisei Carvalho, Machado, Juliana Martins, Gonçalves, Ana Alice Maia, Giunchetti, Rodolfo Cordeiro, Campos-da-Paz, Mariana, Galdino, Alexsandro Sobreira
• Format: Journal Article
• Language: English
• Published: United Arab Emirates 2023
• Subjects: Biotechnology; Humans; Patents as Topic; Rubella - diagnosis; Rubella - epidemiology; Rubella virus - genetics; German measles; recombinant proteins; Rubella; Rubella virus; Rubella antibodies; diagnosis Rubella
• DOI: 10.2174/1872208316666220902094706
• EISSN: 2212-4012

Rubella, caused by the Rubella virus (RV), is considered a mild self-limited illness. However, RV has teratogenic potential. Laboratory investigation plays an important role in both diagnosis and surveillance of the disease. The main methods for diagnosing Rubella are serological assays for the detection of specific IgM and molecular assays for detecting viral RNA. However, some laboratories perform IgG avidity testing, virus isolation and analysis of genetic sequence as tools to help Rubella eradication. The importance of the diagnosis of Rubella involves the appropriate treatment of the disease, because the Rubella clinical symptoms may be similar to those of other diseases, and the population monitoring to avoid new emergent cases. This study addresses different methods of diagnosing Rubella and contributes as a source of knowledge to assist health systems in controlling the disease.
The main objective of this study was to review the available patents regarding Rubella diagnosis published in intellectual property databases, and provides an overview of the technologies available for the diagnosis of Rubella.
The search strategy was based on the keywords searched separately or together using a Boolean operator either in the patent title or abstract the time interval was restricted to patents filed or granted from January 2009 until February 2022. The database used was Google Patents.
This study analyzed 24 patent documents regarding strategies for the diagnosis of Rubella. Of these, 15 patents disclose strategies for detecting Rubella antibodies, 7 patents the detection of Rubella virus nucleic acid, and 2 patents the production of antibodies applied in Rubella diagnosis.
Rubella is still a public health problem in some countries, mainly those in development, especially due to congenital Rubella syndrome, which can cause malformation or fetal death. However, its diagnosis is challenging, due to similarity of symptoms with other diseases, and for this reason, laboratory diagnosis is essential. Studies like this encourage researchers and governments to invest in research to continue the development of new products, using different areas of biotechnology, to solve society's problems, especially diseases that have an impact on global health, such as Rubella.