In-silico Studies, Synthesis, and Antacid Activities of Magnesium (II) Complexes

• Published in: Current drug discovery technologies Vol. 21; no. 6; p. e200324228146
• Main Authors: Jha, Basuki Nath, Kothari, Richa, Agrawal, Anurag
• Format: Journal Article
• Language: English
• Published: United Arab Emirates 2024
• Subjects: Antacids - chemistry; Antacids - pharmacology; Computer Simulation; Coordination Complexes - chemical synthesis; Coordination Complexes - chemistry; Coordination Complexes - pharmacology; H(+)-K(+)-Exchanging ATPase - metabolism; Ligands; Magnesium - chemistry; Magnesium - metabolism; Molecular Docking Simulation; Spectroscopy, Fourier Transform Infrared - methods; keto-enol isomerism; Antacid activity; Mg (II) complexes; schiff base; semicarbazone ligand; spectroscopic characterization
• ISSN: 1875-6220
• DOI: 10.2174/0115701638276401240315084143

Nowadays, acidity is a severe problem worldwide caused by excessive gastric acid secretion by the stomach and proximal intestine.
Antacids are drugs capable of buffering stomach acid. Therefore, in our research work, we have reported the
studies, synthesis, characterization, and evaluation of antacid activities of magnesium (II) complexes via the acid-base neutralization process.
In this research, some magnesium complexes were synthesized and their antacid behavior was compared with marketed products. Also,
studies were performed on H+/K+ ATPase (Proton pump). All synthesized compounds were characterized by various spectroscopic techniques like UV-Vis, FT-IR, XRD, and DSC techniques.
Spectroscopic analysis results showed that the semicarbazone ligand shows keto-enol isomerism and forms a coordinated stable complex with magnesium ions in the crystalline phase. The FT-IR results confirmed the presence of Mg-O stretching, N-H bending, and C=N stretching vibrations in Mg (II) complexes.
The antacid activities of Mg (II) complexes were excellent as compared to the semicarbazone ligand and comparable with that of marketed antacid drugs like ENO, and Pantop-D. Insilco studies also confirmed that semicarbazone ligand and its Mg (II) complexes were both found to be fitted into the active sites of molecular targets, and Mg (II) complexes showed better binding affinities towards macromolecular as compared to semicarbazone ligand.