Description of 3 cases in Vietnam of aspirin desensitization in patients with coronary artery disease and coexisting aspirin hypersensitivity

: Aspirin (ASA) hypersensitivity comprises types I to III (Cox-1 mediated) and types IV and V (IgE antibody mediated). Rapid, low-dose (81-325 mg/day) ASA desensitization regimens are known to be useful in establishing ASA tolerance in patients with coronary artery disease and coexisting ASA/nonster...

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Bibliographic Details
Published in:	The World Allergy Organization journal Vol. 5; no. 11; pp. 170 - 173
Main Authors:	Van Nguyen, Dinh, Chu Chi, Hieu, Van Nguyen, Doan, Craig, Timothy J, van Nunen, Sheryl
Format:	Journal Article
Language:	English
Published:	United States BioMed Central Ltd 15-11-2012 Elsevier
Online Access:	Get full text
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Summary:	: Aspirin (ASA) hypersensitivity comprises types I to III (Cox-1 mediated) and types IV and V (IgE antibody mediated). Rapid, low-dose (81-325 mg/day) ASA desensitization regimens are known to be useful in establishing ASA tolerance in patients with coronary artery disease and coexisting ASA/nonsteroidal anti-inflammatory drug hypersensitivity. We document 3 cases in Vietnam of desensitization to ASA in patients with coronary artery disease and coexisting ASA hypersensitivity. One of these 3 patients had probable immune-mediated hypersensitivity, whereas the remaining 2 had probable Cox-1-mediated reactions. The regimen of desensitization we employed for each patient was designed to account for the probable mechanism of hypersensitivity in the individual and further modified according to the degree of tolerance observed, with all 3 patients eventually achieving a daily cardioprotective dosage of ASA.
ISSN:	1939-4551 1939-4551
DOI:	10.1186/1939-4551-5-11-170