Low Density Lipoprotein Receptor Related Proteins as Regulators of Neural Stem and Progenitor Cell Function

• Published in: Stem Cells International Vol. 2016; no. 2016; pp. 930 - 945-078
• Main Authors: Young, Kaylene, Foa, Lisa, Landowski, Lila M., Auderset, Loic
• Format: Journal Article
• Language: English
• Published: Cairo, Egypt Hindawi Limiteds 01-01-2016; Hindawi Publishing Corporation; John Wiley & Sons, Inc; Hindawi Limited
• Subjects: Apolipoproteins; Cellular signal transduction; Central nervous system; Cholesterol; Colleges & universities; Endoplasmic reticulum; Enzymes; Kinases; Ligands; Lipids; Low density lipoproteins; Medical research; Neurons; Plasma; Proteins; Review; Stem cells; Transcription factors
• ISSN: 1687-966X; 1687-9678; 1687-9678
• DOI: 10.1155/2016/2108495

The central nervous system (CNS) is a highly organised structure. Many signalling systems work in concert to ensure that neural stem cells are appropriately directed to generate progenitor cells, which in turn mature into functional cell types including projection neurons, interneurons, astrocytes, and oligodendrocytes. Herein we explore the role of the low density lipoprotein (LDL) receptor family, in particular family members LRP1 and LRP2, in regulating the behaviour of neural stem and progenitor cells during development and adulthood. The ability of LRP1 and LRP2 to bind a diverse and extensive range of ligands, regulate ligand endocytosis, recruit nonreceptor tyrosine kinases for direct signal transduction and signal in conjunction with other receptors, enables them to modulate many crucial neural cell functions.