High Serum IgG4 Concentrations in Patients with Hashimoto's Thyroiditis

• Published in: International Journal of Endocrinology Vol. 2015; no. 2015; pp. 618 - 623-178
• Main Authors: Górska, Maria, Szelachowska, Małgorzata, Milewski, Robert, Hryniewicka, Justyna, Telejko, Beata, Siewko, Katarzyna, Kościuszko-Zdrodowska, Maria, Popławska-Kita, Anna, Abdelrazek, Saeid Soleman
• Format: Journal Article
• Language: English
• Published: Cairo, Egypt Hindawi Limiteds 01-01-2015; Hindawi Publishing Corporation; John Wiley & Sons, Inc; Hindawi Limited
• Subjects: Age; Antibodies; Body composition; Body fat; Chemokines; Development and progression; Diagnosis; Disease; Endocrinology; Genetic aspects; Hypothyroidism; Immunoglobulin G; Measurement; Medical research; Physiological aspects; Statistical analysis; Thyroid gland; Thyroiditis, Autoimmune; Tumor necrosis factor-TNF; Poland; United States > US; Germany
• ISSN: 1687-8337; 1687-8345
• DOI: 10.1155/2015/706843

Purpose. Since recent reports suggest that Hashimoto thyroiditis (HT) may be associated with IgG4-related disease, we aimed to find out whether the measurement of serum IgG4 allows for the identification of distinct types of HT, with different clinical, sonographic, and serologic characteristics. Methods. The group studied consisted of 53 patients with HT and 28 healthy individuals who underwent thyroid ultrasonography and body composition analysis. Serum concentrations of IgG4, TSH, anti-peroxidase antibodies (TPOAb), anti-TSH receptor antibodies, TNF-α, TGF-β1, Fas Ligand, TRAIL, and chemokines (CXCL9, CXCL11, and CXCL10) were measured by ELISA or radioimmunoassay. Results. The group with IgG4 level >135 IU/ml accounted for 32.5% of the patients. The signs of fibrosis were present in 27.0% of the high-IgG4 patients and in 9.1% of the normal-IgG4 group. The patients with elevated IgG4 required higher doses of L-thyroxine and had significantly lower level of TPOAb (P=0.02) than the non-IgG4-HT individuals and higher TNF-α level in comparison with the controls (P=0.01). Conclusions. Our results suggest that the measurement of serum IgG4 allows for an identification of patients with more rapid progression of HT, requiring higher doses of L-thyroxine. Low TPOAb level and the absence of coexisting autoimmune diseases may suggest distinct pathomechanism of this type of thyroiditis.