Tumor Necrosis Factor Is a Therapeutic Target for Immunological Unbalance and Cardiac Abnormalities in Chronic Experimental Chagas' Heart Disease

Background. Chagas disease (CD) is characterized by parasite persistence and immunological unbalance favoring systemic inflammatory profile. Chronic chagasic cardiomyopathy, the main manifestation of CD, occurs in a TNF-enriched milieu and frequently progresses to heart failure. Aim of the Study. To...

Full description

Saved in:

Bibliographic Details
Published in:	Mediators of Inflammation Vol. 2014; no. 8; pp. 78 - 93
Main Authors:	Lannes-Vieira, Joseli, Britto, Constança, Moreira, Otacilio Cruz, Silva, Andrea Alice, Vilar-Pereira, Glaucia, Pereira, Isabela Resende, Sarmento, Ellen Diana Marinho
Format:	Journal Article
Language:	English
Published:	Cairo, Egypt Hindawi Limiteds 01-01-2014 Hindawi Publishing Corporation John Wiley & Sons, Inc Hindawi Limited
Subjects:	Animals Antibodies, Monoclonal - therapeutic use Chagas Disease - drug therapy Chagas Disease - metabolism Chagas' disease Female Flow Cytometry Health aspects Heart - drug effects Heart - parasitology Heart diseases Heart Diseases - drug therapy Heart Diseases - metabolism Identification and classification Immune response Immunohistochemistry Infliximab Interleukin-10 - metabolism Interleukin-17 - metabolism Mice Mice, Inbred C57BL Nitric Oxide - metabolism Physiological aspects Reverse Transcriptase Polymerase Chain Reaction Trypanosoma cruzi - pathogenicity Tumor necrosis factor Tumor Necrosis Factor-alpha - antagonists & inhibitors Tumor Necrosis Factor-alpha - metabolism
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Be the first to leave a comment!