Squamous Cell Carcinoma of the Lung with Metastasis to the GI Tract Associated with EGFR Exon 19 Deletion

We describe three confirmed cases of squamous cell carcinoma (SCC) of the lung with metastasis to the gastrointestinal (GI) tract, with two having epidermal growth factor receptor (EGFR) exon 19 deletions in all available specimens. One of these patients received EGFR tyrosine kinase directed therap...

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Bibliographic Details
Published in:	Case Reports in Medicine Vol. 2013; no. 2013; pp. 85 - 86-222
Main Authors:	Weiss, Glen J., Liman, Agnes K., Allen, Jeffrey, Cheung, Philip Y., Kukunoor, Rajesh N.
Format:	Journal Article
Language:	English
Published:	Cairo, Egypt Hindawi Limiteds 01-01-2013 Hindawi Puplishing Corporation Hindawi Publishing Corporation Hindawi Limited
Subjects:	Case Report
Online Access:	Get full text
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Summary:	We describe three confirmed cases of squamous cell carcinoma (SCC) of the lung with metastasis to the gastrointestinal (GI) tract, with two having epidermal growth factor receptor (EGFR) exon 19 deletions in all available specimens. One of these patients received EGFR tyrosine kinase directed therapy for a brief period with some symptom relief. Consideration of EGFR exon 19 mutation testing in SCC of the lung, particularly for those with GI tract metastasis, may identify this potentially drug-targetable entity.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Academic Editor: Gottfried J. Locker
ISSN:	1687-9627 1687-9635
DOI:	10.1155/2013/874836