Spithioneines A and B, Two New Bohemamine Derivatives Possessing Ergothioneine Moiety from a Marine-Derived Streptomyces spinoverrucosus

Spithioneines A and B (1 and 2), two new bohemamine-type pyrrolizidine alkaloids possessing an unusual ergothioneine moiety, were isolated from a marine-derived Streptomyces spinoverrucosus. Their structures were elucidated by spectroscopic analysis, CD spectra, and chemical degradation and synthesi...

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Published in:	Organic letters Vol. 17; no. 12; pp. 3046 - 3049
Main Authors:	Fu, Peng, MacMillan, John B
Format:	Journal Article
Language:	English
Published:	United States American Chemical Society 19-06-2015
Subjects:	Biological Products - chemical synthesis Biological Products - chemistry Ergothioneine - chemistry Letter Marine Biology Molecular Structure Pyrrolizidine Alkaloids - chemical synthesis Pyrrolizidine Alkaloids - chemistry Pyrrolizidine Alkaloids - isolation & purification Streptomyces Streptomyces - chemistry
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Abstract	Spithioneines A and B (1 and 2), two new bohemamine-type pyrrolizidine alkaloids possessing an unusual ergothioneine moiety, were isolated from a marine-derived Streptomyces spinoverrucosus. Their structures were elucidated by spectroscopic analysis, CD spectra, and chemical degradation and synthesis. Compounds 1 and 2 are rare natural products that incorporate the amino acid ergothioneine.
AbstractList	Spithioneines A and B (1 and 2), two new bohemamine-type pyrrolizidine alkaloids possessing an unusual ergothioneine moiety, were isolated from a marine-derived Streptomyces spinoverrucosus. Their structures were elucidated by spectroscopic analysis, CD spectra, and chemical degradation and synthesis. Compounds 1 and 2 are rare natural products that incorporate the amino acid ergothioneine. Spithioneines A and B ( 1 and 2 ), two new bohemamine-type pyrrolizidine alkaloids possessing an unusual ergothioneine moiety, were isolated from a marine-derived Streptomyces spinoverrucosus . Their structures were elucidated by spectroscopic analysis, CD spectra, and chemical degradation and synthesis. Compounds 1 and 2 are rare natural products that incorporate the amino acid ergothioneine.
Author	Fu, Peng MacMillan, John B
AuthorAffiliation	University of Texas Southwestern Medical Center at Dallas Department of Biochemistry
AuthorAffiliation_xml	– name: University of Texas Southwestern Medical Center at Dallas – name: Department of Biochemistry
Author_xml	– sequence: 1 givenname: Peng surname: Fu fullname: Fu, Peng – sequence: 2 givenname: John B surname: MacMillan fullname: MacMillan, John B email: john.macmillan@utsouthwestern.edu
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Snippet	Spithioneines A and B (1 and 2), two new bohemamine-type pyrrolizidine alkaloids possessing an unusual ergothioneine moiety, were isolated from a... Spithioneines A and B ( 1 and 2 ), two new bohemamine-type pyrrolizidine alkaloids possessing an unusual ergothioneine moiety, were isolated from a...
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SubjectTerms	Biological Products - chemical synthesis Biological Products - chemistry Ergothioneine - chemistry Letter Marine Biology Molecular Structure Pyrrolizidine Alkaloids - chemical synthesis Pyrrolizidine Alkaloids - chemistry Pyrrolizidine Alkaloids - isolation & purification Streptomyces Streptomyces - chemistry
Title	Spithioneines A and B, Two New Bohemamine Derivatives Possessing Ergothioneine Moiety from a Marine-Derived Streptomyces spinoverrucosus
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