Regulatory Mechanisms and Novel Therapeutic Targeting Strategies for Protein Tyrosine Phosphatases

An appropriate level of protein phosphorylation on tyrosine is essential for cells to react to extracellular stimuli and maintain cellular homeostasis. Faulty operation of signal pathways mediated by protein tyrosine phosphorylation causes numerous human diseases, which presents enormous opportuniti...

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Bibliographic Details
Published in:	Chemical reviews Vol. 118; no. 3; pp. 1069 - 1091
Main Authors:	Yu, Zhi-Hong, Zhang, Zhong-Yin
Format:	Journal Article
Language:	English
Published:	United States American Chemical Society 14-02-2018
Subjects:	Allosteric Regulation Animals Cells Dual Specificity Phosphatase 6 - antagonists & inhibitors Dual Specificity Phosphatase 6 - classification Dual Specificity Phosphatase 6 - metabolism Enzymes Historical account Homeostasis Humans Kinases Modulators Oligomerization Oxidation-Reduction Phosphorylation Protein Multimerization Protein Tyrosine Phosphatases - antagonists & inhibitors Protein Tyrosine Phosphatases - classification Protein Tyrosine Phosphatases - metabolism R&D Reactive Oxygen Species - metabolism Regulatory mechanisms (biology) Research & development Signal Transduction Signaling Tyrosine
Online Access:	Get full text
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