Research on Trypanosoma cruzi and Analysis of Inflammatory Infiltrate in Esophagus and Colon from Chronic Chagasic Patients with and without Mega
To compare parasitism and inflammatory process in esophagus and colon from chronic chagasic patients, immunohistochemistry was carried out to research for T. cruzi and to evaluate the inflammatory infiltrate in the muscular and myenteric plexus in 39 esophagi (20 with and 19 without megaesophagus) a...
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| Published in: | Journal of Tropical Medicine Vol. 2012; no. 2012; pp. 102 - 107 |
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| Main Authors: | , , , , |
| Format: | Journal Article |
| Language: | English |
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Cairo, Egypt
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01-01-2012
Hindawi Puplishing Corporation Hindawi Publishing Corporation Hindawi Limited |
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| Abstract | To compare parasitism and inflammatory process in esophagus and colon from chronic chagasic patients, immunohistochemistry was carried out to research for T. cruzi and to evaluate the inflammatory infiltrate in the muscular and myenteric plexus in 39 esophagi (20 with and 19 without megaesophagus) and 50 colons (25 with and 25 without megacolon). The frequency of T. cruzi in megaesophagus was 20%, and in megacolon it was 4%. No amastigotes were found in organs without mega; considering the total of esophagi (with and without mega), the frequency of T. cruzi would be 10% and 2% in the colon. Myositis and ganglionitis were more frequent and intense in organs with mega compared to those without mega, and in esophagus compared to colon. Qualitatively, inflammatory infiltration in esophagus and colon, with or without mega, was similar, consisting predominantly of T lymphocytes (CD3+), scarce macrophages (CD68+), and rare B lymphocytes (CD20+). |
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| AbstractList | To compare parasitism and inflammatory process in esophagus and colon from chronic chagasic patients, immunohistochemistry was carried out to research for
T. cruzi
and to evaluate the inflammatory infiltrate in the muscular and myenteric plexus in 39 esophagi (20 with and 19 without megaesophagus) and 50 colons (25 with and 25 without megacolon). The frequency of
T. cruzi
in megaesophagus was 20%, and in megacolon it was 4%. No amastigotes were found in organs without mega; considering the total of esophagi (with and without mega), the frequency of
T. cruzi
would be 10% and 2% in the colon. Myositis and ganglionitis were more frequent and intense in organs with mega compared to those without mega, and in esophagus compared to colon. Qualitatively, inflammatory infiltration in esophagus and colon, with or without mega, was similar, consisting predominantly of T lymphocytes (CD3+), scarce macrophages (CD68+), and rare B lymphocytes (CD20+). To compare parasitism and inflammatory process in esophagus and colon from chronic chagasic patients, immunohistochemistry was carried out to research for T. cruzi and to evaluate the inflammatory infiltrate in the muscular and myenteric plexus in 39 esophagi (20 with and 19 without megaesophagus) and 50 colons (25 with and 25 without megacolon). The frequency of T. cruzi in megaesophagus was 20%, and in megacolon it was 4%. No amastigotes were found in organs without mega; considering the total of esophagi (with and without mega), the frequency of T. cruzi would be 10% and 2% in the colon. Myositis and ganglionitis were more frequent and intense in organs with mega compared to those without mega, and in esophagus compared to colon. Qualitatively, inflammatory infiltration in esophagus and colon, with or without mega, was similar, consisting predominantly of T lymphocytes (CD3+), scarce macrophages (CD68+), and rare B lymphocytes (CD20+). |
| Author | Adilha Misson Micheletti Sheila Jorge Adad Thales Parenti Silveira Eliângela de Castro Côbo Eduardo Crema |
| AuthorAffiliation | 1 Disciplina de Patologia Especial, Universidade Federal do Triângulo Mineiro (UFTM), Avenida Getúlio Guaritá 130, Abadia 38045-440 Uberaba, MG, Brazil 2 Disciplina de Cirurgia Digestiva, Universidade Federal do Triângulo Mineiro (UFTM), Avenida Getúlio Guaritá 130, Abadia 38045-440 Uberaba, MG, Brazil |
| AuthorAffiliation_xml | – name: 1 Disciplina de Patologia Especial, Universidade Federal do Triângulo Mineiro (UFTM), Avenida Getúlio Guaritá 130, Abadia 38045-440 Uberaba, MG, Brazil – name: 2 Disciplina de Cirurgia Digestiva, Universidade Federal do Triângulo Mineiro (UFTM), Avenida Getúlio Guaritá 130, Abadia 38045-440 Uberaba, MG, Brazil |
| Author_xml | – sequence: 1 fullname: Crema, Eduardo – sequence: 2 fullname: Silveira, Thales Parenti – sequence: 3 fullname: Micheletti, Adilha Misson Rua – sequence: 4 fullname: Adad, Sheila Jorge – sequence: 5 fullname: Côbo, Eliângela de Castro |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/22131997$$D View this record in MEDLINE/PubMed |
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| CitedBy_id | crossref_primary_10_1007_s00428_012_1299_7 crossref_primary_10_1016_j_healun_2014_01_920 crossref_primary_10_1016_j_rvsc_2020_07_024 crossref_primary_10_1016_j_prp_2017_04_014 crossref_primary_10_1186_s13071_015_0811_8 crossref_primary_10_1128_genomeA_00815_13 crossref_primary_10_1128_IAI_00081_19 crossref_primary_10_1111_tid_12783 crossref_primary_10_1016_j_actatropica_2022_106632 crossref_primary_10_1111_nmo_13102 crossref_primary_10_1128_JVI_01895_12 crossref_primary_10_1007_s00436_015_4371_9 |
| Cites_doi | 10.1016/j.humpath.2007.01.020 10.4269/ajtmh.1997.56.485 10.4269/ajtmh.2001.65.435 10.1007/BF02235488 10.1016/S0035-9203(03)90155-6 10.1016/j.humpath.2008.02.002 10.1590/S0036-46651991000600004 10.4269/ajtmh.1993.48.348 10.1590/S0037-86821997000100018 10.1002/clc.4960101113 10.1017/S0031182005008061 10.1016/S0035-9203(01)90153-1 10.1590/S0036-46651987000400002 10.1016/S0140-6736(05)64761-7 10.1016/S0065-308X(08)60472-8 10.1016/S1471-4922(02)02283-3 10.1007/s004280000319 10.1007/BF01614765 |
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| Contributor | Silveira, Thales Parenti Adad, Sheila Jorge Crema, Eduardo Côbo, Eliângela de Castro Micheletti, Adilha Misson Rua |
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| Copyright | Copyright © 2012 Eliângela de Castro Côbo et al. Copyright © 2012 Eliângela de Castro Côbo et al. 2012 |
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| Editor | Corbett, Carlos E. P. |
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| Title | Research on Trypanosoma cruzi and Analysis of Inflammatory Infiltrate in Esophagus and Colon from Chronic Chagasic Patients with and without Mega |
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