Disruption of an Enterococcus faecium Species-Specific Gene, a Homologue of Acquired Macrolide Resistance Genes of Staphylococci, Is Associated with an Increase in Macrolide Susceptibility
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| Published in: | Antimicrobial Agents and Chemotherapy Vol. 45; no. 1; pp. 263 - 266 |
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| AbstractList | The complete sequence (1,479 nucleotides) of msrC, part of which was recently reported by others using a different strain, was determined. This gene was found in 233 of 233 isolates of Enterococcus faecium but in none of 265 other enterococci. Disruption of msrC was associated with a two- to eightfold decrease in MICs of erythromycin azithromycin, tylosin, and quinupristin, suggesting that it may explain in part the apparent greater intrinsic resistance to macrolides of isolates of E. faecium relative to many streptococci. This endogenous, species-specific gene of E. faecium is 53% identical to msr(A), suggesting that it may be a remote progenitor of the acquired macrolide resistance gene found in some isolates of staphylococci. The complete sequence (1,479 nucleotides) of msrC , part of which was recently reported by others using a different strain, was determined. This gene was found in 233 of 233 isolates of Enterococcus faecium but in none of 265 other enterococci. Disruption of msrC was associated with a two- to eightfold decrease in MICs of erythromycin azithromycin, tylosin, and quinupristin, suggesting that it may explain in part the apparent greater intrinsic resistance to macrolides of isolates of E. faecium relative to many streptococci. This endogenous, species-specific gene of E. faecium is 53% identical to msr (A), suggesting that it may be a remote progenitor of the acquired macrolide resistance gene found in some isolates of staphylococci. The complete sequence (1,479 nucleotides) of msrC, part of which was recently reported by others using a different strain, was determined. This gene was found in 233 of 233 isolates ofEnterococcus faecium but in none of 265 other enterococci. Disruption of msrC was associated with a two- to eightfold decrease in MICs of erythromycin azithromycin, tylosin, and quinupristin, suggesting that it may explain in part the apparent greater intrinsic resistance to macrolides of isolates of E. faecium relative to many streptococci. This endogenous, species-specific gene of E. faecium is 53% identical tomsr(A), suggesting that it may be a remote progenitor of the acquired macrolide resistance gene found in some isolates of staphylococci. Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue AAC About AAC Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy AAC RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0066-4804 Online ISSN: 1098-6596 Copyright © 2014 by the American Society for Microbiology. For an alternate route to AAC .asm.org, visit: AAC |
| Author | Barbara E. Murray Kumthorn Malathum Kavindra V. Singh |
| AuthorAffiliation | Center for the Study of Emerging and Re-emerging Pathogens, 1 Division of Infectious Diseases, Department of Internal Medicine, 2 and Department of Microbiology and Molecular Genetics, 3 The University of Texas Medical School at Houston, Houston, Texas 77030 |
| AuthorAffiliation_xml | – name: Center for the Study of Emerging and Re-emerging Pathogens, 1 Division of Infectious Diseases, Department of Internal Medicine, 2 and Department of Microbiology and Molecular Genetics, 3 The University of Texas Medical School at Houston, Houston, Texas 77030 |
| Author_xml | – sequence: 1 givenname: Kavindra V surname: SINGH fullname: SINGH, Kavindra V organization: Center for the Study of Emerging and Re-emerging Pathogens, The University of Texas Medical School at Houston, Houston, Texas 77030, United States – sequence: 2 givenname: Kumthorn surname: MALATHUM fullname: MALATHUM, Kumthorn organization: Center for the Study of Emerging and Re-emerging Pathogens, The University of Texas Medical School at Houston, Houston, Texas 77030, United States – sequence: 3 givenname: Barbara E surname: MURRAY fullname: MURRAY, Barbara E organization: Center for the Study of Emerging and Re-emerging Pathogens, The University of Texas Medical School at Houston, Houston, Texas 77030, United States |
| BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=915028$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/11120975$$D View this record in MEDLINE/PubMed |
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| Keywords | Nucleotide sequence Macrolide Resistance Streptococcaceae Enterococcus faecium Antibiotic Gene Bacteria Micrococcales Genetics Mutation Antibacterial agent Molecular cloning |
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| Notes | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2 Corresponding author. Mailing address: Center for the Study of Emerging and Re-emerging Pathogens, University of Texas Medical School—Houston, 6431 Fannin, 1.728 JFB, Houston, TX 77030. Phone: (713) 500-6767. Fax: (713) 500-6766. E-mail: infdis@heart.med.uth.tmc.edu. |
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| PublicationTitle | Antimicrobial Agents and Chemotherapy |
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| Publisher | American Society for Microbiology |
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Reddit... The complete sequence (1,479 nucleotides) of msrC, part of which was recently reported by others using a different strain, was determined. This gene was found... The complete sequence (1,479 nucleotides) of msrC , part of which was recently reported by others using a different strain, was determined. This gene was found... |
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| StartPage | 263 |
| SubjectTerms | Amino Acid Sequence Anti-Bacterial Agents Anti-Bacterial Agents - pharmacology Bacteriology Base Sequence Biological and medical sciences DNA, Bacterial - genetics DNA, Bacterial - isolation & purification Drug Resistance, Microbial - genetics Enterococcus faecium Enterococcus faecium - drug effects Enterococcus faecium - genetics Erythromycin - pharmacology Fundamental and applied biological sciences. Psychology Genes, Bacterial - genetics Genetics Mechanisms of Resistance Microbiology Molecular Sequence Data msrC gene Mutation - genetics Reverse Transcriptase Polymerase Chain Reaction Staphylococcus Staphylococcus - genetics tylosin |
| Title | Disruption of an Enterococcus faecium Species-Specific Gene, a Homologue of Acquired Macrolide Resistance Genes of Staphylococci, Is Associated with an Increase in Macrolide Susceptibility |
| URI | http://aac.asm.org/content/45/1/263.abstract https://www.ncbi.nlm.nih.gov/pubmed/11120975 https://journals.asm.org/doi/10.1128/AAC.45.1.263-266.2001 https://search.proquest.com/docview/17760408 https://search.proquest.com/docview/70545411 https://pubmed.ncbi.nlm.nih.gov/PMC90270 |
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