Biosynthetic Polymers as Functional Materials
The synthesis of functional polymers encoded with biomolecules has been an extensive area of research for decades. As such, a diverse toolbox of polymerization techniques and bioconjugation methods has been developed. The greatest impact of this work has been in biomedicine and biotechnology, where...
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Published in: | Macromolecules Vol. 49; no. 12; pp. 4379 - 4394 |
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Main Authors: | , , |
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Language: | English |
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American Chemical Society
28-06-2016
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Abstract | The synthesis of functional polymers encoded with biomolecules has been an extensive area of research for decades. As such, a diverse toolbox of polymerization techniques and bioconjugation methods has been developed. The greatest impact of this work has been in biomedicine and biotechnology, where fully synthetic and naturally derived biomolecules are used cooperatively. Despite significant improvements in biocompatible and functionally diverse polymers, our success in the field is constrained by recognized limitations in polymer architecture control, structural dynamics, and biostabilization. This Perspective discusses the current status of functional biosynthetic polymers and highlights innovative strategies reported within the past five years that have made great strides in overcoming the aforementioned barriers. |
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AbstractList | The synthesis of functional polymers encoded with biomolecules has been an extensive area of research for decades. As such, a diverse toolbox of polymerization techniques and bioconjugation methods has been developed. The greatest impact of this work has been in biomedicine and biotechnology, where fully synthetic and naturally derived biomolecules are used cooperatively. Despite significant improvements in biocompatible and functionally diverse polymers, our success in the field is constrained by recognized limitations in polymer architecture control, structural dynamics, and biostabilization. This Perspective discusses the current status of functional biosynthetic polymers and highlights innovative strategies reported within the past five years that have made great strides in overcoming the aforementioned barriers. The synthesis of functional polymers encoded with biomolecules has been an extensive area of research for decades. As such, a diverse toolbox of polymerization techniques and bioconjugation methods has been developed. The greatest impact of this work has been in biomedicine and biotechnology, where fully synthetic and naturally derived biomolecules are used cooperatively. Despite significant improvements in biocompatible and functionally diverse polymers, our success in the field is constrained by recognized limitations in polymer architecture control, structural dynamics, and biostabilization. This Perspective discusses the current status of functional biosynthetic polymers and highlights innovative strategies reported within the past five years that have made great strides in overcoming the aforementioned barriers. |
Author | Carlini, Andrea S Gianneschi, Nathan C Adamiak, Lisa |
AuthorAffiliation | Department of Chemistry and Biochemistry University of California, San Diego |
AuthorAffiliation_xml | – name: University of California, San Diego – name: Department of Chemistry and Biochemistry |
Author_xml | – sequence: 1 givenname: Andrea S surname: Carlini fullname: Carlini, Andrea S – sequence: 2 givenname: Lisa surname: Adamiak fullname: Adamiak, Lisa – sequence: 3 givenname: Nathan C surname: Gianneschi fullname: Gianneschi, Nathan C email: ngianneschi@ucsd.edu |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/27375299$$D View this record in MEDLINE/PubMed |
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Snippet | The synthesis of functional polymers encoded with biomolecules has been an extensive area of research for decades. As such, a diverse toolbox of polymerization... The synthesis of functional polymers encoded with biomolecules has been an extensive area of research for decades. As such, a diverse toolbox of polymerization... |
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Title | Biosynthetic Polymers as Functional Materials |
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