Biosynthetic Polymers as Functional Materials

The synthesis of functional polymers encoded with biomolecules has been an extensive area of research for decades. As such, a diverse toolbox of polymerization techniques and bioconjugation methods has been developed. The greatest impact of this work has been in biomedicine and biotechnology, where...

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Bibliographic Details
Published in:Macromolecules Vol. 49; no. 12; pp. 4379 - 4394
Main Authors: Carlini, Andrea S, Adamiak, Lisa, Gianneschi, Nathan C
Format: Journal Article
Language:English
Published: United States American Chemical Society 28-06-2016
Online Access:Get full text
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Summary:The synthesis of functional polymers encoded with biomolecules has been an extensive area of research for decades. As such, a diverse toolbox of polymerization techniques and bioconjugation methods has been developed. The greatest impact of this work has been in biomedicine and biotechnology, where fully synthetic and naturally derived biomolecules are used cooperatively. Despite significant improvements in biocompatible and functionally diverse polymers, our success in the field is constrained by recognized limitations in polymer architecture control, structural dynamics, and biostabilization. This Perspective discusses the current status of functional biosynthetic polymers and highlights innovative strategies reported within the past five years that have made great strides in overcoming the aforementioned barriers.
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ISSN:0024-9297
1520-5835
DOI:10.1021/acs.macromol.6b00439