A Helping Hand to Overcome Solubility Challenges in Chemical Protein Synthesis

Although native chemical ligation (NCL) and related chemoselective ligation approaches provide an elegant method to stitch together unprotected peptides, the handling and purification of insoluble and aggregation-prone peptides and assembly intermediates create a bottleneck to routinely preparing la...

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Bibliographic Details

Published in:	Journal of the American Chemical Society Vol. 138; no. 36; pp. 11775 - 11782
Main Authors:	Jacobsen, Michael T, Petersen, Mark E, Ye, Xiang, Galibert, Mathieu, Lorimer, George H, Aucagne, Vincent, Kay, Michael S
Format:	Journal Article
Language:	English
Published:	United States American Chemical Society 14-09-2016
Subjects:	Amino Acid Sequence Chemistry Techniques, Synthetic Fluorenes - chemistry Life Sciences Protein Folding Proteins - chemical synthesis Proteins - chemistry Ribosomal Proteins - chemical synthesis Ribosomal Proteins - chemistry Solubility Viral Proteins - chemistry
Online Access:	Get full text
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