Evaluation of the Xpert Xpress GBS test for rapid detection of group B Streptococcus in pregnant women

Evaluation of the Xpert Xpress GBS test for rapid detection of group B Streptococcus in pregnant women

This was the first study evaluating the performance of the Xpert Xpress group B (GBS) test using rectovaginal swabs from Chinese pregnant women. Compared to the other three assays, the Xpert Xpress GBS test demonstrated high sensitivity and specificity when screening 939 pregnant women for GBS in re...

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Published in:Microbiology spectrum Vol. 12; no. 1; p. e0220623
Main Authors: Wang, Feiling, Yi, Lehui, Ming, Fang, Dong, Rui, Wang, Feng, Chen, Ruirui, Hu, Xiaoling, Chen, Xuri, Sun, Bo, Tang, Yi-Wei, Zhu, Yuanfang, Wu, Lijuan
Format: Journal Article
Language:English
Published: United States American Society for Microbiology 11-01-2024
Subjects:
Clinical Microbiology
direct culture
enrichment culture
Female
group B Streptococcus
Humans
Pregnancy
Pregnancy Complications, Infectious - diagnosis
Pregnant Women
qPCR
Research Article
Streptococcal Infections - diagnosis
Streptococcus agalactiae - genetics
Vagina
Xpert Xpress GBS
group B Streptococcus
Xpert Xpress GBS
direct culture
enrichment culture
qPCR
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Abstract This was the first study evaluating the performance of the Xpert Xpress group B (GBS) test using rectovaginal swabs from Chinese pregnant women. Compared to the other three assays, the Xpert Xpress GBS test demonstrated high sensitivity and specificity when screening 939 pregnant women for GBS in rectovaginal specimens. Additionally, its reduced time to obtain results makes it valuable for the rapid detection of GBS.
AbstractList Group B Streptococcus (GBS) remains the leading cause of serious neonatal infection. Prenatal screening for vaginal and rectal GBS colonization is necessary in late pregnancy. Our objective was to compare the performance of four methods including the Xpert Xpress GBS, standard broth enrichment culture, real-time quantitative PCR (qPCR), and direct culture, for detecting of GBS in rectovaginal specimens. Among 939 pregnant women at 35–37 weeks of gestation recruited in the study, 168 (17.9%) were determined to be GBS-colonized by broth enrichment culture, the gold standard. The sensitivity and specificity of the Xpert Xpress GBS were 94.6% and 95.9%, respectively. The hands-on time and running time of the Xpert Xpress GBS were 1 minute and less than 1 hour, respectively. As a random-access, integrated device, the Xpert Xpress GBS test efficiently and accurately screens rectovaginal swabs for GBS colonization in pregnant women. IMPORTANCE This was the first study evaluating the performance of the Xpert Xpress group B Streptococcus (GBS) test using rectovaginal swabs from Chinese pregnant women. Compared to the other three assays, the Xpert Xpress GBS test demonstrated high sensitivity and specificity when screening 939 pregnant women for GBS in rectovaginal specimens. Additionally, its reduced time to obtain results makes it valuable for the rapid detection of GBS.
ABSTRACT Group B Streptococcus (GBS) remains the leading cause of serious neonatal infection. Prenatal screening for vaginal and rectal GBS colonization is necessary in late pregnancy. Our objective was to compare the performance of four methods including the Xpert Xpress GBS, standard broth enrichment culture, real-time quantitative PCR (qPCR), and direct culture, for detecting of GBS in rectovaginal specimens. Among 939 pregnant women at 35–37 weeks of gestation recruited in the study, 168 (17.9%) were determined to be GBS-colonized by broth enrichment culture, the gold standard. The sensitivity and specificity of the Xpert Xpress GBS were 94.6% and 95.9%, respectively. The hands-on time and running time of the Xpert Xpress GBS were 1 minute and less than 1 hour, respectively. As a random-access, integrated device, the Xpert Xpress GBS test efficiently and accurately screens rectovaginal swabs for GBS colonization in pregnant women. IMPORTANCE This was the first study evaluating the performance of the Xpert Xpress group B Streptococcus (GBS) test using rectovaginal swabs from Chinese pregnant women. Compared to the other three assays, the Xpert Xpress GBS test demonstrated high sensitivity and specificity when screening 939 pregnant women for GBS in rectovaginal specimens. Additionally, its reduced time to obtain results makes it valuable for the rapid detection of GBS.
Group B Streptococcus (GBS) remains the leading cause of serious neonatal infection. Prenatal screening for vaginal and rectal GBS colonization is necessary in late pregnancy. Our objective was to compare the performance of four methods including the Xpert Xpress GBS, standard broth enrichment culture, real-time quantitative PCR (qPCR), and direct culture, for detecting of GBS in rectovaginal specimens. Among 939 pregnant women at 35–37 weeks of gestation recruited in the study, 168 (17.9%) were determined to be GBS-colonized by broth enrichment culture, the gold standard. The sensitivity and specificity of the Xpert Xpress GBS were 94.6% and 95.9%, respectively. The hands-on time and running time of the Xpert Xpress GBS were 1 minute and less than 1 hour, respectively. As a random-access, integrated device, the Xpert Xpress GBS test efficiently and accurately screens rectovaginal swabs for GBS colonization in pregnant women. This was the first study evaluating the performance of the Xpert Xpress group B Streptococcus (GBS) test using rectovaginal swabs from Chinese pregnant women. Compared to the other three assays, the Xpert Xpress GBS test demonstrated high sensitivity and specificity when screening 939 pregnant women for GBS in rectovaginal specimens. Additionally, its reduced time to obtain results makes it valuable for the rapid detection of GBS.
Group B Streptococcus (GBS) remains the leading cause of serious neonatal infection. Prenatal screening for vaginal and rectal GBS colonization is necessary in late pregnancy. Our objective was to compare the performance of four methods including the Xpert Xpress GBS, standard broth enrichment culture, real-time quantitative PCR (qPCR), and direct culture, for detecting of GBS in rectovaginal specimens. Among 939 pregnant women at 35–37 weeks of gestation recruited in the study, 168 (17.9%) were determined to be GBS-colonized by broth enrichment culture, the gold standard. The sensitivity and specificity of the Xpert Xpress GBS were 94.6% and 95.9%, respectively. The hands-on time and running time of the Xpert Xpress GBS were 1 minute and less than 1 hour, respectively. As a random-access, integrated device, the Xpert Xpress GBS test efficiently and accurately screens rectovaginal swabs for GBS colonization in pregnant women.
IMPORTANCEThis was the first study evaluating the performance of the Xpert Xpress group B Streptococcus (GBS) test using rectovaginal swabs from Chinese pregnant women. Compared to the other three assays, the Xpert Xpress GBS test demonstrated high sensitivity and specificity when screening 939 pregnant women for GBS in rectovaginal specimens. Additionally, its reduced time to obtain results makes it valuable for the rapid detection of GBS.
This was the first study evaluating the performance of the Xpert Xpress group B (GBS) test using rectovaginal swabs from Chinese pregnant women. Compared to the other three assays, the Xpert Xpress GBS test demonstrated high sensitivity and specificity when screening 939 pregnant women for GBS in rectovaginal specimens. Additionally, its reduced time to obtain results makes it valuable for the rapid detection of GBS.
Author Chen, Ruirui
Wang, Feiling
Dong, Rui
Hu, Xiaoling
Sun, Bo
Wu, Lijuan
Ming, Fang
Tang, Yi-Wei
Zhu, Yuanfang
Chen, Xuri
Yi, Lehui
Wang, Feng
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  organization: Clinical Affairs, Cepheid , Sunnyvale, California, USA
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  surname: Chen
  fullname: Chen, Xuri
  organization: Department of Obstetrics, Shenzhen Key Medical Discipline, Maternal-Fetal Medicine Institute, Shenzhen Bao'an Women's and Children's Hospital , Shenzhen, Guangdong, China
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  surname: Zhu
  fullname: Zhu, Yuanfang
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Issue 1
Keywords group B Streptococcus
Xpert Xpress GBS
direct culture
enrichment culture
qPCR
Language English
License This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license. https://creativecommons.org/licenses/by/4.0
This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.
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content type line 23
Feiling Wang and Lehui Yi contributed equally to this article. The order of authors was determined by the corresponding author after negotiation.
X.H. and Y.W.T. are employees of Cepheid, the commercial manufacturer of the Xpert Xpress GBS test. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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Snippet This was the first study evaluating the performance of the Xpert Xpress group B (GBS) test using rectovaginal swabs from Chinese pregnant women. Compared to...
Group B Streptococcus (GBS) remains the leading cause of serious neonatal infection. Prenatal screening for vaginal and rectal GBS colonization is necessary in...
Group B Streptococcus (GBS) remains the leading cause of serious neonatal infection. Prenatal screening for vaginal and rectal GBS colonization is necessary in...
IMPORTANCEThis was the first study evaluating the performance of the Xpert Xpress group B Streptococcus (GBS) test using rectovaginal swabs from Chinese...
ABSTRACT Group B Streptococcus (GBS) remains the leading cause of serious neonatal infection. Prenatal screening for vaginal and rectal GBS colonization is...
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SubjectTerms Clinical Microbiology
direct culture
enrichment culture
Female
group B Streptococcus
Humans
Pregnancy
Pregnancy Complications, Infectious - diagnosis
Pregnant Women
qPCR
Research Article
Streptococcal Infections - diagnosis
Streptococcus agalactiae - genetics
Vagina
Xpert Xpress GBS
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Title Evaluation of the Xpert Xpress GBS test for rapid detection of group B Streptococcus in pregnant women
URI https://www.ncbi.nlm.nih.gov/pubmed/38054718
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