Biomarker-Assisted Dose Selection for Safety and Efficacy in Early Development of PNU-100480 for Tuberculosis

• Published in: Antimicrobial Agents and Chemotherapy Vol. 55; no. 2; pp. 567 - 574
• Main Authors: WALLIS, Robert S, JAKUBIEC, Wesley, MILLER, Paul F, KUMAR, Vikas, BEDARIDA, Gabriella, SILVIA, Annette, PAIGE, Darcy, TONG ZHU, MITTON-FRY, Mark, LADUTKO, Lynn, CAMPBELL, Sheldon
• Format: Journal Article
• Language: English
• Published: Washington, DC American Society for Microbiology 01-02-2011; American Society for Microbiology (ASM)
• Subjects: Acetamides - pharmacology; Adolescent; Adult; Animals; Antibiotics. Antiinfectious agents. Antiparasitic agents; Antitubercular Agents; Antitubercular Agents - administration & dosage; Antitubercular Agents - adverse effects; Antitubercular Agents - pharmacokinetics; Antitubercular Agents - therapeutic use; Area Under Curve; Bacterial diseases; Biological and medical sciences; Clinical Therapeutics; Dose-Response Relationship, Drug; Drug Administration Schedule; Human bacterial diseases; Humans; Infectious diseases; Linezolid; Medical sciences; Microbial Sensitivity Tests - methods; Middle Aged; Mycobacterium tuberculosis; Mycobacterium tuberculosis - drug effects; Mycobacterium tuberculosis - growth & development; Oxazolidinones; Oxazolidinones - administration & dosage; Oxazolidinones - adverse effects; Oxazolidinones - pharmacokinetics; Oxazolidinones - pharmacology; Oxazolidinones - therapeutic use; Pharmacology. Drug treatments; Pyrazinamide - pharmacology; Rats; Serum Bactericidal Test; Treatment Outcome; Tuberculosis - drug therapy; Tuberculosis - microbiology; Tuberculosis and atypical mycobacterial infections; Young Adult; Infection; Tuberculosis; Toxicity; Treatment efficiency; Bacteriosis; Development; Biological marker; Artificial selection; Early; Mycobacterial infection; Safety; Dose
• ISSN: 0066-4804; 1098-6596
• DOI: 10.1128/AAC.01179-10

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