Markers of Field Cancerization: Proposed Clinical Applications in Prostate Biopsies

Field cancerization denotes the occurrence of genetic, epigenetic, and biochemical aberrations in structurally intact cells in histologically normal tissues adjacent to cancerous lesions. This paper tabulates markers of prostate field cancerization known to date and discusses their potential clinica...

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Bibliographic Details
Published in:	Prostate Cancer Vol. 2012; no. 2012; pp. 48 - 59
Main Authors:	Bisoffi, Marco, Griffith, Jeffrey K., Jones, Anna C., Trujillo, Kristina A.
Format:	Journal Article
Language:	English
Published:	Cairo, Egypt Hindawi Limiteds 01-01-2012 Hindawi Puplishing Corporation Hindawi Publishing Corporation Hindawi Limited
Subjects:	Review
Online Access:	Get full text
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Summary:	Field cancerization denotes the occurrence of genetic, epigenetic, and biochemical aberrations in structurally intact cells in histologically normal tissues adjacent to cancerous lesions. This paper tabulates markers of prostate field cancerization known to date and discusses their potential clinical value in the analysis of prostate biopsies, including diagnosis, monitoring progression during active surveillance, and assessing efficacy of presurgical neoadjuvant and focal therapeutic interventions.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Academic Editor: Sandra M. Gaston
ISSN:	2090-3111 2090-312X
DOI:	10.1155/2012/302894