Phosphorylation of Histone Deacetylase 8: Structural and Mechanistic Analysis of the Phosphomimetic S39E Mutant

Histone deacetylase (HDAC) enzymes that catalyze removal of acetyl-lysine post-translational modifications are frequently post-translationally modified. HDAC8 is phosphorylated within the deacetylase domain at conserved residue serine 39, which leads to decreased catalytic activity. HDAC8 phosphoryl...

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Bibliographic Details
Published in:	Biochemistry (Easton) Vol. 58; no. 45; pp. 4480 - 4493
Main Authors:	Welker Leng, Katherine R, Castañeda, Carol Ann, Decroos, Christophe, Islam, Barira, Haider, Shozeb M, Christianson, David W, Fierke, Carol A
Format:	Journal Article
Language:	English
Published:	United States American Chemical Society 12-11-2019
Subjects:	Biochemistry, Molecular Biology Chemical Sciences Crystallography, X-Ray Histone Deacetylases - chemistry Histone Deacetylases - genetics Histone Deacetylases - metabolism Humans Life Sciences Molecular Dynamics Simulation Phosphorylation Point Mutation Protein Conformation Repressor Proteins - chemistry Repressor Proteins - genetics Repressor Proteins - metabolism Substrate Specificity
Online Access:	Get full text
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