Isolation and Structure Determination of New Macrolide Antibiotics

• Published in: Journal of natural products (Washington, D.C.) Vol. 55; no. 6; pp. 753 - 759
• Main Authors: Hatfield, George M, Woodard, Ronald W, Son, Jong-Keun
• Format: Journal Article
• Language: English
• Published: Washington, DC American Chemical Society 01-06-1992; Glendale, AZ American Society of Pharmacognosy
• Subjects: Anti-Bacterial Agents - chemistry; Anti-Bacterial Agents - isolation & purification; Anti-Bacterial Agents - pharmacology; Antibiotics (antibacterial agents, antifungal agents); Antibiotics, Antineoplastic - pharmacology; Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents; Applied microbiology; Bacteria - drug effects; Biological and medical sciences; Fundamental and applied biological sciences. Psychology; Macrolides; Magnetic Resonance Spectroscopy; Microbial Sensitivity Tests; Microbiology; Streptomyces - chemistry; Streptomyces - metabolism; Tumor Cells, Cultured - drug effects; Actinomycetales; Antibiotic; Streptomycetaceae; Molecular structure; Streptomyces; Bacteria; Isolation; Actinomycetes; Antibacterial agent; NMR spectrum; Macrolide
• ISSN: 0163-3864; 1520-6025
• DOI: 10.1021/np50084a008

Three new bafilomycin-like compounds PD 118,576-A1 [1], PD 118,576-A2 [2], and PD 118,576-A3 [3] were isolated from a new soil Streptomyces species (WP 3913). The structures of PD 118,576-A1, PD 118,576-A2, and PD 118,576-A3 were elucidated on the basis of spectroscopic studies including 2D nmr.