Use of the Neuropsychiatric Inventory to Characterize the Course of Neuropsychiatric Symptoms in Progressive Supranuclear Palsy

The aim of this study was to determine the neuropsychiatric profile in a cohort of progressive supranucelar palsy (PSP) patients and their dynamic changes over a follow-up period of 1 year. A total of 59 patients were assessed at baseline, while 25 of them were accessible after 1 year of the follow-...

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Bibliographic Details
Published in:	The journal of neuropsychiatry and clinical neurosciences Vol. 30; no. 1; pp. 38 - 44
Main Authors:	Ječmenica-Lukić, Milica, Pekmezović, Tatjana, Petrović, Igor N, Tomić, Aleksandra, Svetel, Marina, Kostić, Vladimir S
Format:	Journal Article
Language:	English
Published:	United States American Psychiatric Association 2018
Subjects:	predictors neuropsychiatric inventory Basal Ganglia Disorders Extrapyramidal Syndromes progressive supranuclear palsy
Online Access:	Get full text
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Summary:	The aim of this study was to determine the neuropsychiatric profile in a cohort of progressive supranucelar palsy (PSP) patients and their dynamic changes over a follow-up period of 1 year. A total of 59 patients were assessed at baseline, while 25 of them were accessible after 1 year of the follow-up. The most common symptoms were apathy and depression, which were also found to be, among other variables, the independent determinants of increased Neuropsychiatric Inventory (NPI) total score. Moreover, apathy deteriorated most profoundly over the follow-up period. The NPI seemed to be a sensitive measure of behavioral changes in PSP.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0895-0172 1545-7222
DOI:	10.1176/appi.neuropsych.17010012