Antioxidative Activity of Sulfur-Containing Compounds in Allium Species for Human Low-Density Lipoprotein (LDL) Oxidation in Vitro

• Published in: Journal of agricultural and food chemistry Vol. 51; no. 24; pp. 7208 - 7214
• Main Authors: Higuchi, Ohki, Tateshita, Koutaro, Nishimura, Hiroyuki
• Format: Journal Article
• Language: English
• Published: Washington, DC American Chemical Society 19-11-2003
• Subjects: Agronomy. Soil science and plant productions; Allium; Allium - chemistry; amino acid derivatives; antioxidant activity; antioxidants; Antioxidants - pharmacology; Biological and medical sciences; Chemical constitution; cysteine; Cysteine - analogs & derivatives; Cysteine - pharmacology; diallyl sulfides; Economic plant physiology; Fundamental and applied biological sciences. Psychology; garlic; General pharmacology; Humans; in vitro studies; Kinetics; Lipid Peroxidation - drug effects; Lipoproteins, LDL - chemistry; low density lipoprotein; Medical sciences; onions; organic sulfur compounds; oxidation; Pharmacognosy. Homeopathy. Health food; Pharmacology. Drug treatments; root vegetables; structure-activity relationships; Sulfoxides - pharmacology; Sulfur Compounds - pharmacology; trisulfides; vinyldithiins; Volatile compound; Sulfur compounds; Monocotyledones; Disease; Allium species; Pharmacognosy; Interspecific comparison; Cholesterol LDL; Antioxidant; Structure function relationship; Biological activity; Allium; low-density lipoprotein; Sulfur containing aminoacid; life-style-related diseases; Liliaceae; Health food; Angiospermae; sulfur-containing compounds; Herbaceous plant; Spermatophyta; antioxidative activity; Life style
• ISSN: 0021-8561; 1520-5118
• DOI: 10.1021/jf034294u

Sulfur-containing compounds contributing to health promotion in Allium species are produced via enzymic and thermochemical reactions. Sulfur-containing amino acids and volatile organosulfur compounds were prepared for an antioxidative assay. The inhibitory activity of S-alk(en)yl-l-cysteines and their sulfoxides, volatile alk(en)yl disulfides and trisulfides, and vinyldithiins in Allium species against lipid hydroperoxide (LOOH) formation in human low-density lipoprotein (LDL) was examined. It was elucidated that the alk(en)yl substituents (methyl, propyl, and allyl) and the number of sulfur atoms in the compounds were important for the antioxidative activity. 3,4-Dihydro-3-vinyl-1,2-dithiin, which is produced by a thermochemical reaction of allyl 2-propenethiosulfinate, exhibited the highest antioxidative activity of human LDL among sulfur-containing compounds. Keywords: Allium species; sulfur-containing compounds; antioxidative activity; life-style-related diseases; low-density lipoprotein