Renally Excretable and Size-Tunable Silver Sulfide Nanoparticles for Dual-Energy Mammography or Computed Tomography
Significant effort has been focused on developing renally clearable nanoparticle agents since efficient renal clearance is important for eventual clinical translation. Silver sulfide nanoparticles (Ag2S-NP) have recently been identified as contrast agents for dual-energy mammography, computed tomogr...
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| Published in: | Chemistry of materials Vol. 31; no. 19; pp. 7845 - 7854 |
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| Main Authors: | , , , , , , |
| Format: | Journal Article |
| Language: | English |
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American Chemical Society
08-10-2019
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| Abstract | Significant effort has been focused on developing renally clearable nanoparticle agents since efficient renal clearance is important for eventual clinical translation. Silver sulfide nanoparticles (Ag2S-NP) have recently been identified as contrast agents for dual-energy mammography, computed tomography (CT), and fluorescence imaging and probes for drug delivery and photothermal therapy with good biocompatibility. However, most Ag2S-NP reported to date are not renally excretable and are observed in vivo to accumulate and remain in the reticuloendothelial system (RES) organs, i.e., liver and spleen, for a long time, which could negatively impact their likelihood for translation. Herein, we present renally clearable, 3.1 nm Ag2S-NP with 85% of the injected dose (ID) being excreted within 24 h of intravenous injection, which is among the best clearance of similarly sized nanoparticles reported thus far (mostly between 20 and 75% of ID). The urinary excretion and low RES accumulation of these nanoparticles in mice were indicated by in vivo CT imaging and biodistribution analysis. In summary, these ultrasmall Ag2S-NP can be effectively eliminated via urine and have high translational potential for various biomedical applications. |
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| AbstractList | Significant effort has been focused on developing renally clearable nanoparticle agents since efficient renal clearance is important for eventual clinical translation. Silver sulfide nanoparticles (Ag2S-NP) have recently been identified as contrast agents for dual-energy mammography, computed tomography (CT), and fluorescence imaging and probes for drug delivery and photothermal therapy with good biocompatibility. However, most Ag2S-NP reported to date are not renally excretable and are observed in vivo to accumulate and remain in the reticuloendothelial system (RES) organs, i.e., liver and spleen, for a long time, which could negatively impact their likelihood for translation. Herein, we present renally clearable, 3.1 nm Ag2S-NP with 85% of the injected dose (ID) being excreted within 24 h of intravenous injection, which is among the best clearance of similarly sized nanoparticles reported thus far (mostly between 20 and 75% of ID). The urinary excretion and low RES accumulation of these nanoparticles in mice were indicated by in vivo CT imaging and biodistribution analysis. In summary, these ultrasmall Ag2S-NP can be effectively eliminated via urine and have high translational potential for various biomedical applications. Significant effort has been focused on developing renally-clearable nanoparticle agents since efficient renal clearance is important for eventual clinical translation. Silver sulfide nanoparticles (Ag 2 S-NP) have recently been identified as contrast agents for dual energy mammography, computed tomography (CT) and fluorescence imaging and probes for drug delivery and photothermal therapy with good biocompatibility. However, most Ag 2 S-NP reported to date are not renally excretable and are observed in vivo to accumulate and remain in the reticuloendothelial system (RES) organs, i.e. liver and spleen, for a long time, which could negatively impact their likelihood for translation. Herein, we present renally-clearable, 3.1 nm Ag 2 S-NP with 85% of the injected dose (ID) being excreted within 24 hours of intravenous injection, which is amongst the best clearance of similarly sized nanoparticles reported thus far (mostly between 20-75% of ID). The urinary excretion and low RES accumulation of these nanoparticles in mice were indicated by in vivo CT imaging and biodistribution analysis. In summary, these ultrasmall Ag 2 S-NP can be effectively eliminated via urine and have high translational potential for various biomedical applications. |
| Author | Lau, Kristen C Maidment, Andrew D. A Cruz, Emma D Hsu, Jessica C Cormode, David P Bouché, Mathilde Kim, Johoon |
| AuthorAffiliation | Department of Bioengineering University of Pennsylvania Department of Radiology |
| AuthorAffiliation_xml | – name: University of Pennsylvania – name: Department of Bioengineering – name: Department of Radiology – name: 1 Department of Radiology, University of Pennsylvania 3400 Spruce St, 1 Silverstein, Philadelphia, PA 19104, USA – name: 2 Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA |
| Author_xml | – sequence: 1 givenname: Jessica C orcidid: 0000-0002-3599-2834 surname: Hsu fullname: Hsu, Jessica C organization: University of Pennsylvania – sequence: 2 givenname: Emma D surname: Cruz fullname: Cruz, Emma D organization: Department of Radiology – sequence: 3 givenname: Kristen C surname: Lau fullname: Lau, Kristen C organization: University of Pennsylvania – sequence: 4 givenname: Mathilde orcidid: 0000-0003-2707-1290 surname: Bouché fullname: Bouché, Mathilde organization: Department of Radiology – sequence: 5 givenname: Johoon orcidid: 0000-0002-1138-5984 surname: Kim fullname: Kim, Johoon organization: University of Pennsylvania – sequence: 6 givenname: Andrew D. A surname: Maidment fullname: Maidment, Andrew D. A organization: Department of Radiology – sequence: 7 givenname: David P orcidid: 0000-0002-8391-9500 surname: Cormode fullname: Cormode, David P email: david.cormode@uphs.upenn.edu organization: University of Pennsylvania |
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| Cites_doi | 10.1021/acsnano.5b02749 10.1186/bcr3210 10.1016/j.addr.2016.09.001 10.1016/j.biomaterials.2012.03.059 10.1039/C4TB01159G 10.1021/es9035557 10.1002/anie.201206059 10.1016/j.biomaterials.2016.06.015 10.1097/RLI.0000000000000246 10.1259/bjr/13169882 10.1016/j.acra.2014.02.017 10.1021/jp501266d 10.1021/nl803405h 10.1021/la403028j 10.1038/nbt1340 10.1007/s00330-015-4152-y 10.1021/acsnano.6b07866 10.1038/ki.1994.32 10.1002/anie.201609043 10.1016/j.biomaterials.2008.12.038 10.1161/CIRCULATIONAHA.105.595090 10.1038/nnano.2007.387 10.1039/C6NR02618D 10.1039/C8NR05203D 10.1038/s41578-018-0038-3 10.1097/RLI.0b013e3182562ab9 10.1021/nl900872r 10.1002/anie.201007321 10.1021/acsnano.5b02635 10.1021/nl801958b 10.1088/0031-9155/61/7/2595 10.1021/nn405701q 10.1097/00004424-198307000-00015 10.1021/es2037405 10.1021/nn5071183 10.1016/j.biomaterials.2010.05.009 10.1016/j.biomaterials.2013.01.089 10.1016/j.colsurfb.2008.07.004 10.1016/j.biomaterials.2007.12.037 10.1002/adem.201700940 10.1021/nn402644g 10.1021/cr980441p 10.1039/C8NR03741H 10.1148/radiol.2463070410 10.12659/MSM.893018 10.1039/c3tb21569e 10.1016/0304-3835(86)90050-9 10.1021/es403527n 10.1259/bjr.20140081 |
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| Title | Renally Excretable and Size-Tunable Silver Sulfide Nanoparticles for Dual-Energy Mammography or Computed Tomography |
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